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Relevancy: 100%
Identification of microsomal Epoxide hydrolase in human lung tissue (Project)
Toxic effects of chemicals are in many cases due to activating reactions leading to reactive metabolites. Reactive metabolites are able to damage cellular macromolecules. On the other hand, reactive metabolites can be enzymatically deactivated. The concentration of reactive metabolites is thus influenced by the balance between activating and deactivating processes. The project is aimed at the...
Funding period: 2008 - 2008
Relevancy: 100%
Effects of different dietary Se-sources for cows on Se-bioavailability from their milk (Project)
Organic trace element sources are becoming more and more important. Nevertheless, con-tradictory data are available concerning the effects of these sources on the trace element content and compounds in milk. In the course of a feeding trial currently running at the re-search farm of the BfR cows are fed organic and inorganic selenium sources. Resulting milk and samples are planned to freece dried...
Funding period: 2008 - 2008
Relevancy: 100%
Investigations on the use of phytogenic feed additives in animal nutrition (Project)
The production of foodstuffs, also of animal origin, will increase over the next decades.Besides quantity of the products, demands on the quality and, caused by the increasing number of farm animals, the question on the environmental compatibility will play an importantrole.Ideal conditions in animal husbandry will reduce some problems e.g. illnesses caused by poor management. But the use and the...
Funding period: 2008 - 2008
Relevancy: 100%
Investigation of the residue behavior of different antibiotics in aqua-cultured shrimps (Project)
In Europe, the use of antibiotics for the treatment of food-producing aquacultures is very restricted. On a global scale and especially in some of the Asian countries being the main producers of aqua-cultured products, the application of a large number of antibiotics (>60 active substances) has been reported.In 2005, the global production of shrimps amounted to 6,091,889 tones. The largest part...
Funding period: 2008 - 2008
Relevancy: 100%
Effect of folate oversupplementation on the proliferation and the expression of relevant genes in colon carcinoma cells (Project)
Recent publications indicate that mandatory fortification of flour with folic acid, which was introduced int the USA and Canada in 1998, let to a significant decrease of neural tube de-fects among newborns. Concurrenly, both countries experienced a temporary increase in the incidence of colon carcinomas (Mason et al., 2007). Additionally, Cole et al. (2007) found in a secondary prevention study...
Funding period: 2008 - 2008
Relevancy: 100%
Determination of the isomerization and oxidation products from long-chain, polyunsaturated conjugated fatty acids in novel oils from the marine micro-alga (Project)
In the requested project it is proposed to investigate the levels of polyunsaturated conjuga¬ted fatty acids in novel oils from the marine micro-alga. Thermic processes like deodorisation may play key roles among the parameters influencing the developing levels of isomerization and oxidation products of long-chain, polyunsaturated conjugated fatty acids. The aim of this project is to develop...
Funding period: 2008 - 2008
Relevancy: 100%
Establishment and development of gentoxicity testing methods - Setup of the COMET assay for ingedients of product (Project)
For genotoxicity testing of chemical ingredients present in cosmetics of commodities such as apparel and others, a variety of toxicological assays have been developed in the past. During the last years the COMET assay was propagated between laboratories. In principle, this assay is suited to investigate different organ tissues or different cell types in a sensitive and reproducible manner. In...
Funding period: 2008 - 2008
Relevancy: 100%
Campylobacter and E. coli ? a network project (CampEc-NET) (Project)
The zoonotic bacteria Campylobacter and Verocytotoxin-producing Escherichia coli (VTEC) have a major impact on public health. Veterinary, medical and food laboratories perform laboratory based surveillance activities related to Campylobacter and VTEC, but the diagnostic methods used often differ. This project aimed at integrating veterinary, food and medical laboratory-based surveillance through...
Funding period: 2007 - 2008
Relevancy: 100%
Detection of Allergens in food: a comparative study on DNA-analytical and immunological methods (Project)
As state of November, 25th, 2005, allergens have to be declared all over the European Un-ion (Directive 2000/13/EG OJ L109, 6.5. 2000). The list of ingredients to be labelled com-prises soybean, peanut and many other food components of animal or plant origin. There is no threshold defined so that low traces of the allergenic commodity are sufficient to require declaration. The control of the...
Funding period: 2007 - 2008
Relevancy: 100%
Investigations in vitro on structure-activity-relationship with respect to a teratogenic potential of flavouring substances (Project)
The purpose of the project is to screen for a possible teratogenic potential of certain flavour-ing substances (e.g. 2-methyl-2-propenoic acid, 2-methyl-2-butenoic acid and 2-methyl-2-pentenoic acid) and natural food ingredients structurally related to the known teratogen val-proic acid. In-vitro-methods such as cell culture, reporter gene assays and Western blot have been used. Inhibition of...
Funding period: 2007 - 2008
