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TRACE: Delivering Integrated Traceability Systems that will enhance Consumer Confidence in the Authenticity of Food (Project)

The 5 years project sponsored by the European Commission through the Sixth Framework Programme will provide consumers with added confidence in the authenticity of European food through complete traceability along entire fork to farm food chains. TRACE will develop cost effective analytical methods integrated within sector-specific and -generic traceability systems that will enable the...


Funding period: 2005 - 2009

Relevancy: 100%

Immunodetection of potential biomarkers for the prediction of early carcinogenic processes in the subacute toxicity test (Project)

Results from the Project ?Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407)? financed by BMBF, indicate towards potential biomarkers and pathways relevant to the early detection of chemically induced cancerogenesis. The relevance of such candidates must...


Funding period: 2007 - 2007

Relevancy: 100%

Determination of coumarin in different food samples (Project)

Coumarin is a naturally occurring compound being present not only in cinnamon and cinnamon containing food products but also in a wide variety of plants. In higher concentrations it exhibits among others hepatotoxicity. From the European Food Safety Authority (EFSA) a Tolerable Daily Intake (TDI) of 0.1 mg/kg body weight was established. In Germany during the last years in food surveillance high...


Funding period: 2007 - 2007

Relevancy: 100%

Production of textiles with defined composition and investigation of migrates (Project)

Dyes and other aid materials in the textile industry are neither notified nor certified. Also azo dyes were used for colouring textiles. The available toxicological data for these substances is incomplete. Some azo dyes are known as carcinogenic and allergenic. Especially from textiles, which were not coloured according to the state of the art substances can migrate and come into contact with the...


Funding period: 2007 - 2007

Relevancy: 100%

Screening assays for toxic and sensitizing substances in mixtures of azo dyes and its metabolites using human keratinocytes (Project)

The aim of the project is to study the potential additive or synergistic toxicity induced by the combined treatment of human keratinocytes (primary culture, HaCaT cell line) with defined mixtures of azo dyes and their metabolites (e.g. from hair dyes, textiles). In addition to the cytotoxic effects the induction of cytokine expression as a measure for the sensitizing potential of the substances...


Funding period: 2007 - 2007

Relevancy: 100%

Expression of xenobiotic metabolizing cytochrome P450 (CYP)-dependent monooxygenases in human keratinocytes and permanent skin cell cultures (Project)

The skin is known as an important target organ for substances released from commodities onto the skin surface, e.g. polycyclic aromatic hydrocarbons (PAHs) from rubber materials. Chemicals such as PAHs are metabolized by cytochrome P450-dependent monooxygenases (CYP) and other enzymes. Various CYP enzymes are expressed in human skin, e.g. CYP1B1, CYP1A1, CYP2B6, CYP2D6, CYP2E1, CYP3A4, CYP2S1. To...


Funding period: 2007 - 2007