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Search for: erz0sxl5g8vvmvn4ys3t2pck0tnkfwpqiy0xemsfsppa1u1ofavfhpib7g9htmdy, 10 of 7966 ResultsSorting
Relevancy: 33%
Determining factors of the toxicity in intestine and liver for two similar sized nanoparticles used in food and packaging: In vitro and in vivo investigation on uptake and mechanisms involved (Project)
...Whilst Al0-NP were detected intra-cellular as smaller (ca. 200nm up to 1µm) or larger agglomerates (ca. 3-5µm) in the Lamina propria of the ileum and in crypts (lacteal) in the jejunum, Al2O3-NP were detected as smaller agglomerates (200nm – 1µm) in the Lamina propria of the jejunum. ...This indicated Al0-NP specific cell membrane changes in differentiated Caco-2 cells, which are not observable in Al2O3-NP or with ionic AlCl3 exposed Caco-2 cells. ...The results show that Al0-NP exposed Caco-2 cells incorporated besides larger nanoparticle agglomerates of ca. 1 to 2µm diameter also smaller nanoparticle agglomerates probably in the range between 100nm and 1 µm. ...
Funding period: 2014 - 2018
Relevancy: 32%
Development of a sustaiable and future-proof reusable system of wine bottles (Project)
...However adds the ordenary one-way glassbottle around 50% to the CO2-footprint of a bottle wine in total. The changing conditions in agricultural production towards sustainable agri-systems and the rising energy-prices are leading more to multi-cycle solutions to save energy and reduce CO2-emissions. ...Thats the reason that the operational group 'Wein-Mehrweg' came together in that particular year to develop an practicable and futrure-proof multi-cycle system for 0,75L-winebottles. In addition, alternatives to glassbottles will also be investigated and evaluated. 5 work packages are planned in our project, which can develop a solution in the form of a reusable system for dealing with several current problems with the involvement of all 20 participating wine producers, 5 associations, one research partner and serveral trading partners....
Funding period: 2022 - 2024
Relevancy: 32%
Methods for outbreak management of Popillia japonica in line with EU plant protection legislation (Project)
...The project shall map 1. The different surveillance strategies used for P. japonica within EU member states (MS), Switzerland and United Kingdom, and what approaches have proven effective in early detection. 2. Which management methods (inclusive plant protection products = PPPs) are approved and officially applicable in the different EU MS or where an indication extension would be quickly feasible (e.g. in case of approval of a PPP for other Scarabaeidae). 3. What is the state of scientific knowledge on the effectiveness and mode of action of all proposed measures, taking into consideration also experience reports from countries outside the EU (especially North America). 4. Which of the proposed measures are particularly suitable in individual outbreak situations (e.g., grassland, agricultural land, public green, private gardens, outside the cropland or (semi) natural areas....) and how do pedoclimatic and landscape characteristics affect their effectiveness....
Funding period: 2024 - 2026
Relevancy: 32%
Cellular uptake, metabolism and transport of food constituents in cell culture models (Project)
...The objective of the project is to investigate the molecular mechanisms of cellular uptake, metabolism and transepithelial transport of bioactive food compounds like polyphenols, carotenoids in a number of in vitro model systems such as in vitro digestion/Caco-2cell/Transwell model system. See for references: Bub, A, Watzl, B, Heeb, D, Rechkemmer, G, and Briviba, K (2001) Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. ...Watzl B, Bub A, Pretzer G, Roser S, Barth SW, Rechkemmer G. (2004) Daily moderate amounts or red wine or alcohol have no effect on the immune system of healthy men. ...Nedovic, Springer, pp211-252 Briviba K, Schollenberger M, Rodehutscord M, Greiner R (2017) Dephosphorylation of myo-inositol phosphates in the in vitro intestinal Caco-2 cell model. International Journal of Food Sciences and Nutrition, Vol. 69 (2018), H. 1S. 46-51 Briviba, K, Schnäbele, K, Schwertle, E, Blockhaus, M, and Rechkemmer, G. (2001) ß-Carotene Inhibits Growth of Human Colon Carcinoma Cells In Vitro by Induction of Apoptosis. ...
Funding period: 2001 - 2028
Relevancy: 32%
Metabolic activation and inactivation of food carcinogens 5-hydroxymethylfurfural and furfuryl alcohol in humans, mice and rats (Project)
...In addition, FFA activation will be studied monitoring tissue distributions of macromolecular methylfuran adducts in transgenic mouse lines expressing human SULTs (1A1/1A2) and in knock-out lines lacking endogenous Sults (1a1 and 1d1). ...The FFA-related DNA adduct N2-((furan-2-yl)methyl)-2'-deoxyguanosine (N2-MFdG) was detected in DNA samples of different tissues. ...Also, HMF-related DNA adducts were not detected in human tissue samples, whereas DNA adducts of FFA such as N2-MFdG were detectable in tissue samples of human lung and to a lesser extend in liver, kidney and colon. ...
Funding period: 2014 - 2015
Relevancy: 32%
Development of methods for detection of obesogenic substances (Project)
...Within this project, work on HepaRG and HepG2 cells by use of High-Content-Screening- (HCS) and High-Throughput-Screening- (HTS) methods should be conducted. Additionally extra-hepatic cell-lines from other tissues involved in regulation of fatty acid metabolism and energy homeostasis (like e.g. 3T3-L1 Zellen, differentiating to adipocytes) should be used and tested whether they are responsive to known and potential obesogenes. These systems could be an important part of a testbattery based on an AOP for steatosis and obesity. The murine cell line 3T3 L1 has been established that allows a direkt analysis of adipocyte differentiation. ...
Funding period: 2017 - 2018
Relevancy: 32%
Characterization of vibrio cholerae non-O1, non-O139 from seafood by genome sequencing and virulence-associated phenotypic properties (Project)
...The strains belong to more than 200 serogroups and are widespread in aquatic environments[1]. A number of reports have demonstrated that strains of these serogroups can cause diarrheal diseases or local infections but don’t have the ability to cause epidemic cholera outbreaks [2]. ...The combined results of these investigations will allow to perform an assessment of the potential risk associated with these group of bacteria. [1] Chatterjee et al. (2009) J Clin Microbiol 47(4):1087-1095 [2] Ceccarelli et al. (2015) Appl Enviro Microbiol. 81, 1909-1918. [3] Schirmeister ... Strauch (2014) Eur J Clin Microbiol Infect Dis. 33:767-78. [4] Shin et al.(2011) MBio 2:e00106-11...
Funding period: 2019 - 2019
Relevancy: 32%
Collaborative project: a contribution of viticulture to the goals of the COP21-conference in Paris: sensor utilization in viticulture with minimized CO2-footprint and fungus-resistant cultivars - subproject 3 (Project)
...The project Vitisoil comprises five work packages. WP0 is a preparatory work package to establish and test innovative sensor systems. WP1 comprises a field experiment with deep incorporation of green manure, compost of selected quality, and biochar into vineyard soils of the Federal Julius Kühn Institute for grapevine breeding at Siebeldingen. ...AP4 comprises information and knowledge transfer of growers and cooperatives. ...
Funding period: 2018 - 2021
Relevancy: 32%
Quantification of weed competition in organically grown vining peas under field conditions (Project)
...For this purpose, plant samples were analyzed for their concentrations of N, P, K and Mg and biological N2 fixation was measured using the 'extended difference method'. ...In comparison to control plots, which were manually kept free of weeds, yield reduction amounted to 0 to 49 % averaging 15 %. Relationships between the reduction in crop yield and weed biomass revealed a weed dry matter threshold of 40 g/m² at pea harvest, below which no yield losses occurred. The biological N2-fixation of the pea crops was to some extent depending on yield and nitrogen supply and ranged from 0 to 69 kg N/ha. ...
Funding period: 2007 - 2008
Relevancy: 32%
FOR 536 P5: Quantification and biogeochemical modeling of C and N turnover processes and biosphere-atmosphere exchange of C and N compounds (Project)
...Yuesi Wang Field measurements in MAGIM II will be restricted to obtain a full year dataset of N2O, CH4 and CO2 exchange for the sites ungrazed 1999 and winter-grazed. ...To obtain a regional set of CO2/H2O fluxes for model testing ultralight flights with onboard EC measurements of CO2/H2O fluxes will be performed. ...SWAT and CMF (regional hydrology models, P7), sward production model FOPROQ and sheep model (P3/ P4) and SAMT (GIS-coupled wind erosion model, P9), are delivering important driving and initialization parameters (e.g. ...
Funding period: 2004 - 2016
