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Relevancy: 100%
FloMo-CTC: FLOw dynamical vessel MOdel for Circulating Tumor Cells (Project)
Circulating tumor cells (CTCs) are the seed of metastasis. However, most disseminating cancer cells perish in the circulation, with less than 0.01% of CTCs surviving (Valastyan and Weinberg, 2011). Considering that this selection process is one of the most critical steps in metastasis formation, there is still limited knowledge about the factors supporting cell survival in the human vasculature....
Funding period: 2024 - 2027
Relevancy: 100%
Vascularised 3D Branched Organoid-on-Chip Culture of COPD (Project)
The aim is to develop 3D human airway bronchotubules from healthy and COPD diseased cells of the basal airways, airway smooth muscle and fibroblasts. This will help to elucidate the developmental processes and specific genetic risk factors underlying airway remodeling in COPD. Cell-cell communication and cellular repair and differentiation pathways in different chimeric cultures of healthy and...
Funding period: 2024 - 2027
Relevancy: 100%
Development of a culture system for ex vivo 3D microscopy of living tissue for personalized cancer immunotherapy (Project)
The aim of this project is to develop an ex vivo culture system for living tissue that enables non-invasive cellular imaging of immune responses in the intact tumor microenvironment over several days. Using higher harmonic generation microscopy, the 3D tissue architecture will be visualized without staining to enable the investigation of the migration and effector function of fluorescently...
Funding period: 2024 - 2026
Relevancy: 100%
Preclinical models for rare tumors to advance precision oncology development (Project)
The overall aim of the project is to establish preclinical models for two versatile, rare tumor types, ATC and ACC, for the comprehensive analysis of the response to immunotherapy and resistance mechanisms. Based on these two entities, two fundamental aspects will be addressed: i) to develop solid protocols for the establishment of co-cultures that can be applied in immunooncology and used for...
Funding period: 2024 - 2027
Relevancy: 100%
Influence of flavors during the use of new tobacco-containing and tobacco-free products for inhalation on puffing behavior, nicotine kinetics, short-term lung function and cytokines in the blood (Project)
The objective is to examine the nicotine kinetics of novel tobacco-free, nicotine-containing products, predominantly flavoured, in consumers. The health and addiction risks associated with traditional tobacco consumption are well documented in the literature and supported by long-term data. The plethora of novel nicotine consumption modalities have hitherto been the subject of minimal...
Funding period: 2024 - 2027
Relevancy: 100%
DAM-SN-CREATE – Concepts for Reducing the Effects of Anthropogenic pressures and uses on marine Ecosystems and on biodiversity (Project)
DAM-SN-CREATE – Concepts for Reducing the Effects of Anthropogenic pressures and uses on marine Ecosystems and on biodiversity
Funding period: 2024 - 2027
Relevancy: 100%
New Approach Methodologies (NAM) for the identifcation of developmental toxicity of chlorinated paraffins on nematodes (C. elegans) (Project)
The aim of the project is to use the model organism C. elegans to test whether chlorinated paraffines (CP) have a developmental (neuro)toxic effects. This supports some of the data requirements of EFSA (EFSA Journal 2020;18(3):5991) and ECHA (https://echa.europa.eu/documents/10162/a2a733c0-7ee0-7c29-9162-703d636b3f87).
Funding period: 2024 - 2025
Relevancy: 100%
Bacteriophage Competence Centre (Project)
The tasks and objectives of the Bacteriophage Competence Center include providing scientific advice to the Federal Ministry of Food and Agriculture (BMEL), evaluating current research developments on bacteriophages, researching efficient usage and detection of bacteriophages in the food chain, establishing a bacteriophage strain collection for exchange and deposit of bacteriophages within the...
Funding period: 2024 - 2029
Relevancy: 100%
From evidence to implementation: an evidence assessment scheme for prioritised nutrition policy measures (Project)
Using the example of sugar-sweetened beverage taxation, this collaborative project between MRI (Dept. of Nutritional Behaviour), Thünen-Institut (Institute of Market Analysis) and Paderborn University (Chair of Public Health Nutrition) seeks to develop an evidence assessment scheme for nutrition policy measures.
Funding period: 2025 - 2027
Relevancy: 100%
German-Colombian Training and Demonstration Project for Agroecology (Project)
Project objective: Agroecological approaches with a high impact on food security and the socio-economic situation of marginalized and vulnerable groups as well as on the protection of climate and biodiversity are increasingly available. Expected project results: • Result 1: Validation and Demonstration: Innovative agroecological approaches have been tested and validated with respect to their...
Funding period: 2024 - 2026
