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SFB 670 TP7: Function of heterotetrameric adaptor complexes in phagosome maturation (Project)
Tierische Zellen exprimieren 4 heterotetramere Adaptorkomplexe (AP-1, AP-2, AP-3 und AP-4), welche die Sortierung von Membranproteinen in sich bildende Transportvesikel vermitteln. AP-2 erfüllt diese Funktion bei der Bildung von Clathrin-coated Vesicles im Rahmen der Endocytose von der Plasmamembran, während die anderen 3 Adaptoren eine entsprechende Funktion am trans-Golgi-Netzwerk (TGN) und in...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP8: Inhibition of AAV infection by intracellular defence mechanisms (Project)
Until recently 11 different AAV serotypes have been described, which differ in their tropism due to the use of different cellular receptors and to differences in the cellular reaction towards the infection. Hepatocytes provide a strong example. Less than 10% of hepatocytes in mouse livers are stably transduced with AAV2, although nearly all hepatocytes contain vector genomes 1 day after...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP9: Cell autonomous defense in the control of hepatitis B virus infection (Project)
Human hepatitis B virus (HBV) is a non-cytopathic virus establishing long-term persistent infection. Its replication is tightly controlled in an infected cell by cell-autonomous mechanisms, which mainly target the maturation of viral capsids. In the first part of the project, we will investigate how the cell prevents HBV capsid maturation, and how the viral X-protein helps to escape that control....
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP10: Cell autonomous control of human papillomavirus infection (Project)
Human papillomaviruses (HPV) infect keratinocytes of skin and mucosa, where they induce benign or malignant proliferative lesions. Long term goal of this SFB project is to elucidate cell autonomous defence mechanisms of keratinocytes against HPV, and how the viruses cope with these defence mechanisms. This part of the project focusses on a novel mechanism activated by synthetic dsRNA (polyIC),...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP11: Antiviral defence mechanisms in liver sinusoidal endothelial cells (Project)
Liver sinusoidal endothelial cells (LSEC) take up viruses from the bloodstream, but are not productively infected by these viruses. We plan to characterize the molecular mechanisms in LSEC, which are involved in recognition of the model DNA virus MCMV. Moreover, we will investigate, which signal pathways are involved in induction of type I interferon, inhibition of viral replication and increase...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP12: Molecular mechanisms of dendritic cell signal transduction subsequent to cellular infection by Vaccinia Virus or L. monocytogenes (Project)
This project aims at the characterization of cell-autonomous signal transduction in dendritic cells during infection with L. monocytogenes or vaccinia virus, respectively. The first part aims at the elucidation of the role of beta-2 integrins during phagocytosis. Our working hypothesis is that PRRmediated signals result in defined conformational changes in integrin molecules and that these...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP13: Induced Receptor Endocytosis in the Cell-Autonomous Plant Basal Immune Response (Project)
Perception of bacterial flagellin in Arabidopsis is mediated by the receptor kinase FLS2, which triggers several cell-autonomous defense responses, activation of signalling cascades, and is cellularly endocytosed from plasma membranes. Here, we will investigate flagellin-mediated endocytosis in detail: regulatory factors will be identified, FLS2 containing vesicles will be protein biochemically...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP15: Cell-autonomous role of TLR-induced signalling pathways in antibacterial immunity (Project)
The elicitation of effective host defence against microbial pathogens requires the early detection of infectious agents and the expression of genes regulating the anti-microbial responses. The NF-κB and p38 signalling pathways are activated upon recognition of microbial components by Toll-like receptors and are involved in the regulation of immune responses to infection. Our aim is to investigate...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP17: Role of insulin signal transduction in the regulation of innate immune response (Project)
keine Angaben
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP18: Intracellular perception of fungal effectors and initiation of signalling by allelic NB-LRR receptors (Project)
In plants, innate immune responses are triggered by a repertoire of membrane-anchored and intracellular receptors. The predominant type of receptors mediating strain-specific immunity to pathogen- derived effectors resides inside plant cells. We aim to unravel the molecular mechanisms underlying the recognition of isolate-specific fungal effectors and initiation of resistance signalling by...
Funding period: 2006 - 2010
