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Relevancy: 100%
Metabolic markers of diet and physical activity in humans (Project)
The impact of short and long term physical activity on the human metabolom is investigated. Data from human intervention studies focussing on acute and regular physical activity/fitness are analysed. We aim to identify activity associated metabolite profiles and pathways to explore their relevance in human disease prevention. Kistner S, Rist MJ, Döring M, Dörr C, Neumann R, Härtel S, Bub A (2020)...
Funding period: 2017 - 2022
Relevancy: 100%
miRNA – their role as modulators of metabolic effects (Project)
miRNAs are non-coding small RNA molecules. They modulate gene expression in several tissues through binding to complementary mRNAs. miRNAs are produced in various cell types (e.g. skeletal muscle after physical activity) and secreted into the circulation, which enables them to exert metabolic effects. Moreover, they can be ingested via dietary sources. It is discussed that miRNAs as modulators of...
Funding period: 2019 - 2022
Relevancy: 100%
Implementation and Standardization of Microbiota Analyses (Project)
The physiological impact of human nutrition is strongly modulated by the microorganisms which are mainly living in our large intestine (gut microbiota). Therefore, it is necessary to understand the interactions between nutrition, physiology and microbiota. To study these interactions many novel methods are used and constantly further developed. The obtained results are highly dependent of the...
Funding period: 2017 - 2022
Relevancy: 100%
Impact of thermal food processing on energy utilisation in humans (Project)
The impact of thermal processing of raw foods on energy harvest and utilisation is not fully understood. Processes like protein denaturation or the production of resistant starches are expected to affect the energy value of a meal. Calculation of the energy content by merely using the Atwater system might underestimate caloric values. Perturbation of the equilibrium of energy intake and energy...
Funding period: 2020 - 2023
Relevancy: 100%
Comparision of different methodogical approaches in the personalized nutrition (Project)
Personalized nutrition (PN) is an emerging field, getting increased focus in nutritional research as well as in nutrition industry. One can observe that the concept of PN is used inconsistently throughout the literature, revealing different definitions and understandings of what PN means. The aim of this project is to review, compare and evaluate, which approaches are currently available in the...
Funding period: 2019 - 2023
Relevancy: 100%
Impact of diet and exercise intensity on metabolic effects (Project)
Exercise intensity has an important impact on fitness and health. In this project we will investigate different exercise intensities on human metabolism under controlled diet and standardised conditions by means of metabolic profiling and pathway analysis to finally explore their relevance in human disease prevention.
Funding period: 2018 - 2021
Relevancy: 100%
Influence of dietary pulses on gut barrier function (Project)
A impaired gut barrier function is associated with various diseases such as obesity-associated inflammation or inflammatory bowel diseases. Dietary pulses could influence gut barrier function, due to their nutrient composition (high content of fiber, phytochemicals and protein). Even though epidemiological studies suggest that pulse consumption is associated with beneficial health effects, the...
Funding period: 2017 - 2023
Relevancy: 100%
Nutritional evaluation of caloric and non-caloric sweeteners (Project)
The average daily intake of sugars (glucose and fructose containing sugars) in Germany exceeds the recommended maximum intake recommended by nutrition societies. Excessive sugar consumption is associated with the development of overweight and its comorbidities. Due to these undesirable effects, the National Reduction and Innovation Strategy: Less sugar, fat and salt in ready-made products aims to...
Funding period: 2020 - 2023
Relevancy: 100%
PROMISE Study - PRedictors linking Obesity and gut MIcrobiomE (Project)
Key drivers of obesity include overconsumption of energy-dense, and nutrient-poor foods, which have a profound impact on the composition and functionality of the gut microbiome. Alterations to the microbiome may play a critical role in obesity by affecting energy extraction from food and subsequent energy metabolism and fat storage. The PROMISE study characterizes in particular the gut microbiome...
Funding period: 2018 - 2022
Relevancy: 100%
Health effects of increased legume consumption in humans (Project)
Pulses increase satiety, improve glycaemic control and cholesterol concentrations, and reduce body weight. Therefore, pulses could contribute to diets preventing overweight and associated diseases. Food based dietary guidelines across Europe recommend a higher intake of pulses. However, pulse consumption in European countries and particularly in Germany is low. Convenient pulse products aiming to...
Funding period: 2019 - 2022
