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Relevancy: 100%
Molecular characterization of the interaction between perfluoroctanoic acid (PFOA) and the hepatocyte nuclear factor 4alpha (HNF4alpha) (Project)
Perfluoroctanoic acid (PFOA) is needed for the fabrication of various industrial products. PFOA is chemically and biologically inert; it is a global contaminant of water and soil. Con-taminated foodstuff such as drinking water, fish, eggs and game are the main sources for oral uptake of PFOA by the consumer (experts report by the BfR on PFOS and PFOA in food; Sept. 11th 2008). PFOA is...
Funding period: 2011 - 2011
Relevancy: 100%
Gene expression profiling to elucidate the cancerogenic effects of breakdown products of 1-Methoxyindol-3-methylglucosinolates (MIM-GL) from Brassica vegetables (Project)
Brassica vegetables have been highly valued by large groups of the population in Germanydue to their beneficial health effects. Recently, the group of Prof. Glatt (DIfE) could showthat the consumption of raw and steamed broccoli and other Brassica vegetables resulted incharacteristic DNA adducts in human oral mucosa and in leucocytes. Also after feedingbroccoli to mice and rats adducts were...
Funding period: 2011 - 2011
Relevancy: 100%
Haemoglobin adducts of glycidol as marker of exposure of glycidol fatty acid esters:Development of methods and human trial (Project)
During refinement of plant oil, used since beginning of the 20th century, fatty acid esters of3-monochloropropanediol (3-MCDP) and glycidol are formed as heat-generated foodtoxicants, as discovered recently. Due to its genotoxic and cancerogenic properties as anepoxide, especially an exposure to glycidol would be critical. However, several questionsregarding kinetic aspects are unsolved (degree...
Funding period: 2011 - 2011
Relevancy: 100%
Bioavailability of cyanide from marzipan (human study) (Project)
Cyanogenic glycosides are contained in many plants (e.g. bitter almond and apricot kernels as amygdalin) as a mechanism of self-protection to herbivorous animals. In order to give a bitter taste, the kernels mentioned are in part used for the production of marzipan and persipan. In the European Union, a long-standing maximum level for cyanide of 50 mg/kg is allowed (sum of free and...
Funding period: 2011 - 2011
Relevancy: 100%
Influence of simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) on the intestinal toxicity of silver nanoparticles (Project)
Ingested nanoparticle will be absorbed in the intestine after crossing the acidic environment of the stomach. The particles come into contact and interact with body fluids and with the ingested foods. These interactions may influence the intestinal toxicity of the nanoparticles. Therefore, the influence of the digestion processe on the toxicity of silver nanoparticles should be studied using...
Funding period: 2011 - 2011
Relevancy: 100%
Analysis of effects from trans-fatty acids on miRNA expression profiles of human colon cells (Project)
Trans-fatty acids (TFA) are generated during industrial oil hardening and refinement processesat high temperatures and have diverse adverse health effects. While there is a clearcorrelation between the consumption of TFAs and an increased risk for coronary heart diseases,a potential cancer risk is still controversially discussed.Small non-coding RNAs, microRNAs (miRNAs), are involved in...
Funding period: 2011 - 2011
Relevancy: 100%
Cell cycle effects on the endocrine system and phase I metabolism (Project)
Substances with potential endocrine activities are of increasing concern for consumer protection. Likewise they are in the focus of public debate, academia and politics. The Federal Ministry for Food, Agriculture and Consumer Protection has thus called for increased research in the field of endocrine disruptors. However, despite intensive research we still know too little as to grasp the...
Funding period: 2011 - 2011
Relevancy: 100%
Metabolism of polyaromatic hydrocarbons by the microbiome of the skin (Project)
Many polycyclic aromatic hydrocarbons (PAHs) can be considered as classical carcinogens. Metabolic activation is a frequent prerequisite for their toxicity. In our industrialised society PAHs have become ubiquitous. Thus exposure to PAHs is inevitable as they are taken up via the food chain, inhalation and skin absorption.The toxicological assessment of PAHs tends to focus on their metabolism in...
Funding period: 2011 - 2011
Relevancy: 100%
Proteomic analysis of cellular changes after treatment with contact allergens in human monocytic cell lines and in primary dendritic cells. 2017: Transcriptomic and proteomic Analysis of T cells and monocyte-derived dendritic cells (Project)
A wide range of chemicals may induce allergic contact dermatitis. In the development of allergic contact dermatitis two phases can be separated: sensitization and elicitation. During sensitization contact allergens or sensitizers penetrate through the skin barrier and interact with epidermal dendritic cells, which then become activated and migrate into local lymph nodes to induce T cell-mediated...
Funding period: 2011 - 2017
Relevancy: 100%
Nano-imaging methods for visualization of nanoparticles in vitro and in vivo: Analysis of uptake, distribution and quantitative assessment (Project)
Increasing numbers of products furnished with nanoparticles require careful analysis of possible adverse health effects in humans. By reducing particle size toward nanoscale ranges novel and partially unexpected physicochemical properties appear. Sometimes such properties are of advantage and favor, thus explaining the increasing abundance of nanoparticles in products at the market. However, this...
Funding period: 2012 - 2016
