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Relevancy: 48%

Change in serum TSH levels as a function of iodine intake and thyroid volume - an in-depth evaluation of the study KiGGS (Project)

...For statistical analyses in final regression models, only those children were included for whom none of the available parameters (including fT3 and fT4 measurements) suggested pathophysiologic changes in thyroid status (n=6101).In contrast to the conventional doctrine, also in children with healthy thyroid function, urinary iodine excretion (iodine status) was significantly positively associated with TSH (P less than 0.05; adjusted for sex, age, body surface area, BMI, fT3/fT4 ratio and time of blood sampling). Children with better iodine status showed, on average, an about 0.2 µU/mL higher TSH level than children with lower iodine status. ...In parallel, children with smaller thyroid volume (long-term better iodine supply) had significantly higher TSH levels (P less than 0.001, fully adjusted). Short-term iodine status (spot urine) and thyroid volume were negatively associated in the basic linear regression model (P less than 0.05, adjusted for sex and body surface area); however, this association lost statis-tical significance after full adjustment of the model. ...


Funding period: 2012 - 2013

Relevancy: 47%

Effects of selection for high and low locomotor activity in the domestic fowl (Project)

...In sixth generation, the level of GLA was approximately halved in the low and doubled in the high line compared to the control (7.2, 14.9 and 28.7 recordings/h). Estimated heritability of locomotor activity in the low and high line was 0.38 and 0.33, respectively. ...


Funding period: 2014 - 2019

Relevancy: 47%

Collaborative project: Avoidance of boar taint by breeding and novel boar taint recording system – Subproject 2 (Project)

...Hence, the objective of this study was: Measuring of boar taint and evaluation of breeding strategies to reduce boar taint. 1010 entire boars (Pietrain×F1) were performance tested within 5 stations. ...Within a sire or dam line, 5 or 9 generations are needed to reduce the proportion of high risk boars from 50% to 5%. ...This innovative method is the 1st step in the development of an automatic and fast measurement system of boar taint....


Funding period: 2009 - 2012

Relevancy: 47%

Collaborative project: Avoidance of boar taint by breeding and novel boar taint recording system – Subproject 3 (Project)

...Hence, the objective of this study was: Measuring of boar taint and evaluation of breeding strategies to reduce boar taint. 1010 entire boars (Pietrain×F1) were performance tested within 5 stations. ...Within a sire or dam line, 5 or 9 generations are needed to reduce the proportion of high risk boars from 50% to 5%. ...This innovative method is the 1st step in the development of an automatic and fast measurement system of boar taint....


Funding period: 2009 - 2012

Relevancy: 47%

Collaborative project: Avoidance of boar taint by breeding and novel boar taint recording system – Subproject 4 (Project)

...Hence, the objective of this study was: Measuring of boar taint and evaluation of breeding strategies to reduce boar taint. 1010 entire boars (Pietrain×F1) were performance tested within 5 stations. ...Within a sire or dam line, 5 or 9 generations are needed to reduce the proportion of high risk boars from 50% to 5%. ...This innovative method is the 1st step in the development of an automatic and fast measurement system of boar taint....


Funding period: 2009 - 2012

Relevancy: 47%

Collaborative project: Avoidance of boar taint by breeding and novel boar taint recording system – Subproject 5 (Project)

...Hence, the objective of this study was: Measuring of boar taint and evaluation of breeding strategies to reduce boar taint. 1010 entire boars (Pietrain×F1) were performance tested within 5 stations. ...Within a sire or dam line, 5 or 9 generations are needed to reduce the proportion of high risk boars from 50% to 5%. ...This innovative method is the 1st step in the development of an automatic and fast measurement system of boar taint....


Funding period: 2009 - 2012

Relevancy: 47%

Collaborative project: Avoidance of boar taint by breeding and novel boar taint recording system – Subproject 1 (Project)

...Hence, the objective of this study was: Measuring of boar taint and evaluation of breeding strategies to reduce boar taint. 1010 entire boars (Pietrain×F1) were performance tested within 5 stations. ...Within a sire or dam line, 5 or 9 generations are needed to reduce the proportion of high risk boars from 50% to 5%. ...This innovative method is the 1st step in the development of an automatic and fast measurement system of boar taint....


Funding period: 2009 - 2012

Relevancy: 47%

Further Risk Management fort the EC listed Anoplophora Species, A. chinensis and A. glabripennis (Project)

...Sub-goals for the JKI-part are 1. practical application of an isothermal amplification based molecular identification method (LAMP) using a portable machine (GENIE II) for Anoplophora glabripennis (ALB) and A. chinensis (CLB) and 2. the development of contingency plans for the mentioned Anoplophora species. Plan: Concerning goal 1: At start of the project a technology transfer will be carried out with the UK partner FERA. ...The following parts will be covered: a ) biology, b) experiences in eradication campaigns, c) legal background, d) diagnosis, e) eradication, f) regional general committments, g) public awareness campaigns and e) finances. ...


Funding period: 2014 - 2015

Relevancy: 47%

Bioactivity and mechanisms (antigenotoxic, antioxidative, modulation of signal transduction and barrier function) of food and food constituents (Project)

...Furthermore, the bioavailability of these nutrients is determined by use of appropriate cell systems (e.g. Caco-2/Transwell system). Briviba K, Pan L, Rechkemmer G. (2002) Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. ...Innovative Food Science & Emerging Technologies, 20, 238-243. 1. Briviba, K., Gräf, V., Walz, E., Guamis, B., Butz, P. (2016) Ultra high pressure homogenization of almond milk: Physico-chemical and physiological effects. ...Gille, A., Hollenbach, R., Trautmann, A., Gomez, M.R., Krüger, R., Bischoff, S.C., Posten, C., Briviba, K. (2020) Lipophilic compounds, but not fucoxanthin, mediate the genotoxic effect of photoautotrophic grown Phaeodactylum tricornutum in Caco-2 and HT-29 cells. ...


Funding period: 2001 - 2028

Relevancy: 47%

Berlin-Brandenburg Research Platform BB3R with Integrated Graduate Education 'Innovations in the 3R Research - Genetic Engineering, Tissue Engineering and Bioinformatics' - Subproject 4: 'Individualized pain suppression in mice' (Work program Dept. 9) and 'Development of a nanotoxicology test platform for testing the inhalation toxicity of nanoparticles in vitro' (work program Dept. 7) (Project)

...The aim of this project is to investigate the efficacy of buprenorphine in three commonly used mouse inbred strains (C57BL/6J, Balb/cJ and 129S1/SvImJ). In addition, it will be determined whether differences in the efficacy of buprenorphine are due to strain-specific differences in the metabolism of the animals. ...Based on the findings, improved recommendations for the dosage of buprenorphine for different mouse strains should be given in the future in order to minimize pain during the experiment (refinement). Work program Dept. 9 (Prof. Schönfelder): Basal pain sensitivity differed considerably between the mouse strains with Balb/cJ mice being the most and 129S1/SvImJ mice the least sensitive strain. ...While the analgesic effect of buprenorphine increased in C57BL/6J and Balb/cJ mice with the higher administered dose, the analgesic effect remained stable in 129S1/SvImJ mice. ...


Funding period: 2014 - 2018