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Development of methods for cleavage of azo dyes by human skin bacteria in vitro (Project)

Preceding to toxicological investigations of the metabolism of the azo dyes (e. g. direct blue 14, disperse orange 3) analytical methods and appropriate methods for the sample preparation (e. g. from cultures of bacteria) shall be developed and validated. For the quantification of azo dyes and splitting products/metabolites in extracts of textiles and in mixtures from toxicological...


Funding period: 2002 - 2006

Relevancy: 100%

Development of screening assays for the assessment of the toxicity of migrants from commodities in keratinocytes (Project)

Studies on toxic and sensitizing potential of chemically defined mixtures of substances and migrants from cosmetics and commodities in human keratinocytes (primary keratinocytes, HaCat cell line). The cytotoxic effects are characterized by assays for toxicity (neutral red assay) and markers for proliferation (Ki67- immunoreactivity) and apoptosis (with TUNEL and Hoechst 33342 staining). For the...


Funding period: 2002 - 2006

Relevancy: 100%

Evaluation of endpoints in addition to MTT for predicting skin irritation potential of chemical substances with in vitro human reconstructed skin models. (Project)

Phase 1 of the ECVAM validation study (Project No. 1342-426) has shown that the in vitro tests can successfully discriminate clear-cut irritating chemicals from those chemicals which do not irritate the skin. However, recent new international regulations require a third class of skin irritancy to be predicted: mild irritants. The current project aimes in identifying promising toxicological...


Funding period: 2002 - 2006

Relevancy: 100%

Validation Study Human Exposure of Non-Professionals to Wood Preservatives (Project)

For the coming approval procedure for wood preservatives according to the national regulations a complete and realistic estimation of the primary exposure of users and the secondary exposure of consumers is an indispensable precondition.According to German and Austrian considerations the TECHNICAL NOTES FOR GUIDANCE - HUMAN EXPOSURE TO BIOCIDAL PRODUCTS - GUIDANCE ON EXPOSURE ESTIMATION of the...


Funding period: 2004 - 2005

Relevancy: 100%

European tracking and tracing backbone solution feasibility study (Project)

This work package deals with the basic framework layer 'Infrastructure and Multi-Dimensional Tracking and Tracing Needs'. This work package links up (work group) with the various stakeholders in the provision of baseline system solutions, especially solutions that assure tracking and tracing capability and allow its extension with transparency information. This involves system providers, the...


Funding period: 2009 - 2011

Relevancy: 100%

Integrated project: Epidemiological research network: Foodborne Infections in Germany; Project: Quantitative Risk Assessment fo human Campylobacter infections due to consumption of chicken meat (Project)

The assessment of the risk of Campylobacteriosis due to consumption of chicken meat has to be done in Germany according to the international recommended procedure of quantitative microbiological risk assessment (QRA). The concept of the QRA has been elaborated in the international framework of Codex Alimentarius and is based on a systematically approach for estimation of the risk of foodborne...


Funding period: 2002 - 2005

Relevancy: 100%

Specification of information and information layers with relevance for environmental, ethical or social concerns (Project)

The work package deals with the information layer and focus, after organization of the work group, on the specification of information and information layers with relevance for food safety and quality or for environmental, ethical or social concerns. It involves literature reviews, the analysis and documentation of monitoring and reporting schemes, and expert consultations on the specification of...


Funding period: 2009 - 2011

Relevancy: 100%

Establishing of a wine data bank for analytical parameters for wines from Third Countries (WINE DB) (Project)

The aim of the project is the extension of the sampling and measuring procedures such as stabile isotopes to candidate countries in East Europe as laid down in Reg. EEC No. 2729/2000 from December 2000, 14th and to receive and evaluate authentic sample from there. In addition to isotopic data all samples will be analysed for other parameters to check their importance for the proof of authenticity...


Funding period: 2002 - 2005