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Relevancy: 100%
Use of darkened heating plates ("dark brooders") in the rearing of chicken and effect on behavior and animal welfare during rearing and the subsequent fattening and laying period (Project)
Use of darkened heating plates ("dark brooders") in the rearing of chicken and effect on behavior and animal welfare during rearing and the subsequent fattening and laying period
Funding period: 2025 - 2026
Relevancy: 100%
Establishment and characterization of a human induced pluripotent stem cell-based system as an alternative model and complement to the KPC mouse in oncology research. (Project)
The project aims to genetically modify a commonly and easily available human iPSC line to combine tamoxifen-inducible Cre-mediated expression of mutant KRASG12D under control of the endogenous KRAS promoter with TP53 knockout, similar to current mouse models. The Cre recombinase (coupled to two ERT2 estrogen receptors) will be permanently expressed from the human ROSA26 genomic safe harbor locus,...
Funding period: 2024 - 2027
Relevancy: 100%
Vascularised 3D Branched Organoid-on-Chip Culture of COPD (Project)
The aim is to develop 3D human airway bronchotubules from healthy and COPD diseased cells of the basal airways, airway smooth muscle and fibroblasts. This will help to elucidate the developmental processes and specific genetic risk factors underlying airway remodeling in COPD. Cell-cell communication and cellular repair and differentiation pathways in different chimeric cultures of healthy and...
Funding period: 2024 - 2027
Relevancy: 100%
Preclinical models for rare tumors to advance precision oncology development (Project)
The overall aim of the project is to establish preclinical models for two versatile, rare tumor types, ATC and ACC, for the comprehensive analysis of the response to immunotherapy and resistance mechanisms. Based on these two entities, two fundamental aspects will be addressed: i) to develop solid protocols for the establishment of co-cultures that can be applied in immunooncology and used for...
Funding period: 2024 - 2027
Relevancy: 100%
FloMo-CTC: FLOw dynamical vessel MOdel for Circulating Tumor Cells (Project)
Circulating tumor cells (CTCs) are the seed of metastasis. However, most disseminating cancer cells perish in the circulation, with less than 0.01% of CTCs surviving (Valastyan and Weinberg, 2011). Considering that this selection process is one of the most critical steps in metastasis formation, there is still limited knowledge about the factors supporting cell survival in the human vasculature....
Funding period: 2024 - 2027
Relevancy: 100%
Influence of flavors during the use of new tobacco-containing and tobacco-free products for inhalation on puffing behavior, nicotine kinetics, short-term lung function and cytokines in the blood (Project)
The objective is to examine the nicotine kinetics of novel tobacco-free, nicotine-containing products, predominantly flavoured, in consumers. The health and addiction risks associated with traditional tobacco consumption are well documented in the literature and supported by long-term data. The plethora of novel nicotine consumption modalities have hitherto been the subject of minimal...
Funding period: 2024 - 2027
Relevancy: 100%
Development of a culture system for ex vivo 3D microscopy of living tissue for personalized cancer immunotherapy (Project)
The aim of this project is to develop an ex vivo culture system for living tissue that enables non-invasive cellular imaging of immune responses in the intact tumor microenvironment over several days. Using higher harmonic generation microscopy, the 3D tissue architecture will be visualized without staining to enable the investigation of the migration and effector function of fluorescently...
Funding period: 2024 - 2026
Relevancy: 100%
Synthesis of isotopically labelled enniatins (Project)
The aim of the project is the synthesis of important enniatins and beauvericin, which are labeled with stable isotopes of carbon (13C) and nitrogen (15N), in order to subsequently integrate them into the analytical method established at the National Reference Laboratory (NRL) for mycotoxins and plant toxins. This is highly relevant for the fulfillment of legal tasks. The use of methods using...
Funding period: 2024 - 2025
Relevancy: 100%
New Approach Methodologies (NAM) for the identifcation of developmental toxicity of chlorinated paraffins on nematodes (C. elegans) (Project)
The aim of the project is to use the model organism C. elegans to test whether chlorinated paraffines (CP) have a developmental (neuro)toxic effects. This supports some of the data requirements of EFSA (EFSA Journal 2020;18(3):5991) and ECHA (https://echa.europa.eu/documents/10162/a2a733c0-7ee0-7c29-9162-703d636b3f87).
Funding period: 2024 - 2025
Relevancy: 100%
DAM-SN-CREATE – Concepts for Reducing the Effects of Anthropogenic pressures and uses on marine Ecosystems and on biodiversity (Project)
DAM-SN-CREATE – Concepts for Reducing the Effects of Anthropogenic pressures and uses on marine Ecosystems and on biodiversity
Funding period: 2024 - 2027
