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Relevancy: 100%
Carbon and nutrient storage of forest sites within the forest monitoring networks of Rhineland-Palatinate (BZE, Level II) (Project)
Assessment of biomass and element storage in tree layers, in the understorey and in forest soils of 165 sites of the national soil survey (BZE) and 6 sites of the intensive forest monitoring in Rhineland-Palatinate. Derivation of general evaluation methods and pattern of element storage that are valid for forest monitoring sites across Germany.
Funding period: 2010 - 2011
Relevancy: 100%
SFB 670 TP4: Role of sphingomyelinase for the membrane-bound antibacterial effector mechanisms (Project)
Recruitment of antimicrobial enzymes to the phagosome via vesicular transport processes essentially contributes to the regulation of oxidative and non-oxidative antibacterial mechanisms. We have previously shown the importance of acid Sphingomyelinase (ASMase) for the control of intra-cellular bacteria. In this project we aim at characterizing the molecular mechanisms by which the lipid-modifying...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP10: Cell autonomous control of human papillomavirus infection (Project)
Human papillomaviruses (HPV) infect keratinocytes of skin and mucosa, where they induce benign or malignant proliferative lesions. Long term goal of this SFB project is to elucidate cell autonomous defence mechanisms of keratinocytes against HPV, and how the viruses cope with these defence mechanisms. This part of the project focusses on a novel mechanism activated by synthetic dsRNA (polyIC),...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP15: Cell-autonomous role of TLR-induced signalling pathways in antibacterial immunity (Project)
The elicitation of effective host defence against microbial pathogens requires the early detection of infectious agents and the expression of genes regulating the anti-microbial responses. The NF-κB and p38 signalling pathways are activated upon recognition of microbial components by Toll-like receptors and are involved in the regulation of immune responses to infection. Our aim is to investigate...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP17: Role of insulin signal transduction in the regulation of innate immune response (Project)
keine Angaben
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP20: Distinction of self versus viral RNA by RIG-I and implication for viral infection (Project)
Specifically, the following questions will be answered: a) What are the exact structural requirements for immunorecognition of 5´triphosphate RNA? b) Is 5´triphosphate RNA the direct ligand for RIG-I? c) How is the distinction of viral 5´triphosphate RNA from self RNA in cells accomplished? d) Does detection of viral RNA by RIG-I require active viral replication? e) How can an optimal antiviral...
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP AP2: Cell autonomous defenses regulatory myeloid cells (regMZ) for control of intracellular pathogens granuloma (Project)
keine Angaben
Funding period: 2006 - 2010
Relevancy: 100%
SFB 670 TP AP1: Synthetic Nucleoside Analogs for the Activation of NOD Proteins (Project)
The modulation of specific biological function by means of small molecules opens important options for biomedical research and, in certain cases, even paves the way for the development of new therapeutic concepts. Within this project, synthetic organic chemistry will be used to generate libraries of small molecules, i.e. lipophilic carbocyclic nucleoside analogs. These compounds will then be used...
Funding period: 2006 - 2010
Relevancy: 100%
Collaborative project: Development of efficient high throughput (HT) techniques for selection of grapevine cultivars with high acid stabilty, 1: Development of markers for acid content for MAS in crossbreeding of Vitis vinifera - subproject 3 (Project)
Climate change will cause major changes to viticulture in future decades, as many traditional varieties show best performance in the cool German climate. The correspondingly high organic acid production is an important factor for quality in wine production. Molecular markers linked with quality parameters would enable early selection in breeding, largely independent of environmental factors....
Funding period: 2011 - 2014
Relevancy: 100%
Interaction between irrigation and varieties of vegetables peas, bush beans, spinach and onions, taking into account the expected climate change Saxony (Project)
keine Angaben
Funding period: 2010 - 2015
