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In-vitro bioavailability and toxicity of phloridzin loaded nano- and submicron chitosan particles

Project

Food and consumer protection

This project contributes to the research aim 'Food and consumer protection'. Which funding institutions are active for this aim? What are the sub-aims? Take a look:
Food and consumer protection


Project code: MRI-LBV-08-1030 Chitosanprojekt
Contract period: 01.12.2016 - 31.12.2020
Purpose of research: Experimental development
Keywords: Nanotechnology

The delivery of bioactive compounds through carrier systems and thereby the enhancement of the compounds’ bioavailability is of great interest. Recent studies indicate that especially a particle size within the nanometer range can impact the bioavailability of nutrients from food matrices. Phloridzin is a secondary plant metabolite with anti-diabetic activity but low bioavailability. We hypothesize that the encapsulation of phloridzin in nano-scaled chitosan particles increases the in-vitro bioavailability more than its encapsulation in submicron-scaled chitosan particles. To prove this hypothesis, we encapsulate phloridzin in formulations of different particle size. The in-vitro bioavailability will be tested in cell culture tests. Furthermore, in-vitro toxicity tests will be carried out.

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Subjects

Framework programme

BMEL Frameworkprogramme 2008

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