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PROMISE Study - PRedictors linking Obesity and gut MIcrobiomE
Project
Project code: MRI-PBE-08-1010-promise
Contract period: 01.02.2018
- 01.12.2022
Purpose of research: Experimental development
Key drivers of obesity include overconsumption of energy-dense, and nutrient-poor foods, which have a profound impact on the composition and functionality of the gut microbiome. Alterations to the microbiome may play a critical role in obesity by affecting energy extraction from food and subsequent energy metabolism and fat storage. The PROMISE study characterizes in particular the gut microbiome as well as the plasma and urine metabolome in 2 populations with different metabolic disease risk (Healthy Pacific and New Zealand European women aged between 18 and 45 years) and different body fat profiles (normal and obese). It investigates (1) the role of gut microbiome composition and functionality in obesity, (2) the interactions between dietary intake, eating behaviour, taste perception, sleep and physical activity, and their impact on the gut microbiome, and (3) associations between biomarkers of biological and behavioural risk factors referred to above and specific body fat profiles. This study provides data enabling the identification of distinct roles for diet, taste perception, sleep, and physical activity in women with different body fat profiles in modifying the gut microbiome and its impact on obesity and metabolic health. It will advance the understanding of the etiology of obesity and guide future prevention strategies involving specific dietary and microbiota-based approaches.
Section overview
Subjects
- Physiology of Nutrition
Framework programme
Funding programme
Excutive institution
MRI - Department of Physiology and Biochemistry of Nutrition (MRI-PBE)