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Imprint
Development of novel vaccine concepts against zoonotic pulmonary infections using the Venezuelan encephalitis equine virus replicon particle vaccine platform (OneHealth Vakzine - VRP)
Project
Project code: FLI-IfI-08-Ri-0780
Contract period: 01.07.2020
- 31.08.2021
Purpose of research: Experimental development
Zoonotic infections such as pulmonary tuberculosis cause chronic and deadly pathology in wildlife, livestock and humans. So far new vaccines against tuberculosis focus on single species solutions. However, in light of the WHO OneHealth concept, development of zoonotic vaccines against zoonotic infections should be of highest priority. Yet, investigations of the immunogenicity of the same vaccine against the same pathogen across different species are lacking. Therefore, this project focuses on systematically comparing the immune response to new zoonotic vaccines between different natural host species and experimental animal models. So far, such efforts were limited by the tools available to study the immune system in wildlife or livestock compared to studies in humans or small animal models. Single cell transcriptomics (scRNaseq) offers the opportunity to expand our tool set and knowledge of primary immune cells in understudied but relevant species in the context of zoonotic diseases. In this 1-year pilot project, we aim to compare the in vitro response of immune cells from mucosal sites and peripheral blood to different novel zoonotic vaccine concepts against tuberculosis across several mammalian species. At the same time, the goal is to gain insight into the characteristics of mucosal tissue immune cells across different species using systems comparative immunology.
Section overview
Subjects
- Animal health
