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Dynamics of avian influenza in a changing world. Coordination (DELTA-FLU)
Project
Project code: FLI-IMVZ+IVD-08-HV-0044, 727922
Contract period: 01.06.2017
- 30.11.2022
Budget: 1,425,000 Euro
Purpose of research: Inventory & Assessment
DELTA-FLU- aims at elucidating the mechanisms of bird flu. An international consortium of 10 highly renowned research institutions from all over the world will now bundle expertise in different research fields to promote strategies for the prevention and control of this disease. The project which started on June 1st will be funded by the European Union for 5 years; the Friedrich-Loeffler-Institut (FLI) will act as coordinator. Today and tomorrow the involved project partners from Venice, Rotterdam, Ghent, Edinburgh, Sweden and even Hong Kong meet at the FLI on the Isle of Riems. This kick-off meeting is a first get together of the project partners and provides an opportunity for scientific exchange. The last fowl plague epidemics caused by the pathogen H5N8 has been the so far most severe one in Europe. The causative agents of avian influenza/bird flu naturally undergo constant and rapid change and can cause devastating worldwide outbreaks in wild birds and domestic poultry within a short time. Some pathogens have the potential to be transmitted to mammals and humans thus representing a threat for human health. Research on this issue requires global interdisciplinary solutions. Therefore, the DELTA-FLU consortium is composed of highly renowned experts from Europe, North America and Asia. The project partners will conduct research on the dynamic mechanisms of avian influenzaviruses in poultry and other hosts as well as on the viral, host-related and environmental factors which are crucial for the replication and spread of these pathogens. A better understanding of these mechanisms and factors is essential for the design of effective strategies for diagnostics, prevention and control. The FLI on the Isle of Riems will act as coordinator of DELTA-FLU; co-coordinator will be the ERASMUS University Medical Center (EMC, Rotterdam). In particular the excellent laboratory and experimental animal facilities of the FLI are a crucial prerequisite for conducting molecular biological analyses of the pathogenicity of different avian influenzaviruses and for answering the question which factors are essential for the viruses’ pathogenic effect. Animal studies in chickens, ducks, mice, and ferrets will provide insights into the pathogenicity, i.e. the induction, development and severity of disease in different host animal species. Furthermore, the consortium intends to conduct investigations on the viruses’ stability in the environment and on their activation by host-encoded proteins (enzymes) as well as on the immune reaction of the respective host and the evasive manoeuvers of the viruses. In addition, DELTA-FLU will conduct research on key issues, such as the questions how fowl plague viruses are maintained in the wild bird population and can be spread over long distances, which factors are relevant for introduction of avian influenzaviruses into domestic poultry holdings and which role pigs play in a possible transmission to humans. One crucial aim of the project will be to elucidate the mechanisms which turn harmless influenzaviruses into dangerous fowl plague pathogens.
Section overview
Subjects
- Animal health
- Wildlife Biology
Framework programme
Funding programme
Excutive institution
FLI - Institute of Molecular Virology and Cell Biology (FLI - IMVZ)
