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Uptake and toxicity of nanoparticles regarding coating and ion release in Caco-2-coculture
Project
Project code: BfR-LMS-08-1322-553
Contract period: 01.03.2013
- 31.12.2013
Purpose of research: Applied research
Products based on nanotechnology or containing NPs are already manufactured in the field of electronics, consumer products, and the pharmaceutical industry and are beginning to impact the food-associated industries. Here, nanotechnology tools are used in the entire food chain, for example, during cultivation (agriculture), industrial processing, and food packaging. In addition, nanotechnology is being used to enhance the nutritional aspects of foods by means of adding NPs. Therefore the use of nanoparticles as a carrier for bioactive substances in foods is an ongoing method to improve the bioavailability of substances. Major materials used are silver, metal oxides and titanium.
Decrease of particle size in the nanoscale has been identified as a main parameter for the increased toxicity of different materials. Accumulation of metal and metal oxide Nano-Materials is seen in lower animals and in laboratory animals. Accumulation of these particles is seen especially in liver, spleen and kidney. In this project uptake and toxicity of Nano particles regarding the size, coating and ion release in Caco-2-coculture will be studied.
Furthermore Caco-2 co-culture will be used to extend the standard intestine-model.
Section overview
Subjects
- Physiology of Nutrition
- Toxicology