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BfR - Department 6: Chemicals Safety (BfR - SiP)
Institution
Section overview
Description
The remit of the department comprises the health risk assessment of plant protection products and biocides, which are summarised under the collective term 'pesticides' following the structural reorganisation of the BfR, based on the definition in Directive (EC) No. 2009/128/EC establishing a framework for Community action to achieve the sustainable use of pesticides.
The central tasks of the department include the determination of the inherent toxic properties and dose-effect relationships of active substances and pesticides, the classification and labelling of active substances in pesticides, the derivation of toxicological limit values, the determination of the exposure of humans, production animals and pets and the derivation of risk mitigation measures and maximum residue concentrations with the aim of avoiding harmful impacts on the health of humans and animals. In addition, the department reviews analytical monitoring methods and works on the development and improvement of regulatory testing and assessment strategies and technical guidelines.
The research activities of the department are primarily geared towards support for regulatory procedures, at the current time above all in the fields of 'combination effects' and 'dermal absorption'.
Activities
- Research
Parent institution
Coordinated projects
- Applicability of in silico tools for the prediction of dermal absorption for pesticides
- Application of 2-DE-based proteomics for biomarker detection in human plasma
- Application of 2-DE-based proteomics in vitro
- Application of LC-MS QTrap technology in the simultaneous determination of plant protection products residues
- Array based analysis of endocrine-disrupting properties of selected plant protection products in the low dose range in vitro
- Assay of toxic compounds in smoke of water pipes
- Assessment of dermal absorption of pesticides (DA Assessment)
- Assessment of pesticide metabolites with the use of MetaPath, (Q)SAR and toxicological data from the eASB database at BfR
- Biomarker Quantification by Multiplexing: Analyses of hormone and zytokine level after exposure of blood and skin samples to active substances(Endpoints Endocrine effects, Immunotoxicity)
- Characterisation of in vitro models for the prediction of transplacental transport of xenobiot-ics and analysis of the role of ATP-binding cassette (ABC) transporters
- Combination of in vitro Pre-Screening Test and (Q)SAR-models for identification of the induced type of sensitization by pesticide active substances and co-formulants
- Comparative Cytotoxicity of Plant Protection Products and their Active Ingredients
- Cumulative Effects of Active Ingredients and Co-formulants in Plant Protection Products
- Cytochrom P450 (CYP 2E1)-dependent metabolism in genetically modified cell lines
- Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407)
- Determination of CYP2F-related enzyme activities in human lung tissue
- Determination of the expression of the messenger RNA (mRNA) of xenobiotic-metabolizing Cytochrome P450 (CYP) enzymes in human lung tissue
- Development of a multi-polar method for monitoring pesticide metabolites in drinking water and raw water of drinking water treatment by LC-MS/MS
- Development of a simple and universal analytical method for the simultaneous determination of pesticides in tap water
- Development of an integrated testing strategy to reduce animal testing for plant protection product hazard and risk assessment
- Examination of flame retardants with emphasis on polybrominated diphenyl ethers (PBDEs) in human mothers milk from Germany
- Exploratory study on the evaluation of the relationship betweenemissions from printers and copy machines in offices and health complaints
- Expression of xenobioticametabolising Cytochrome P450 enzymes in human CD 34+ bone marrow stem cells
- Further development of in silico models for prediction for mutagenicity of pesticides - (Q)SAR
- Genetic polymorphisms and variability of cytochrom P450 enzymes
- Grant on supporting EFSA in preparing the guidance on endocrine disruptors (Endocrine Disruptoren)
- Hepatotoxic combination effects of food contaminants and active substances of pesticides
- Hepatotoxic combination effects of multiple residues of pesticides in vivo und in vitro
- Identification and prevalidation of hepatocellular biomarkers for detection and prediction of carci-nogenic effects of chemicals (part 1)
- Identification of CYP2F1 and CYP2S1 in human lung tissue
- Identification of microsomal Epoxide hydrolase in human lung tissue
- Identification of protein-biomarkers in human- and mouse-plasma after exposure to Dioxin.
- Immunodetection of potential biomarkers for the prediction of early carcinogenic processes in the subacute toxicity test
- Impact of chemical structure, physico-chemical substance properties, and study design on the dermal absorption rates of pesticidal/biocidal active ingredients
- Influence of different extraction procedures on the recovery of pesticide residues analysed by liquid chromatographic methods
- Influence of formulation parameters on absorption of pesticides across the skin
- Influence of pesticide co-formulants on oral bioavailability of active substances
- Influence of pesticide co-formulants on the oral bioavailability of active substances
- International Validation of a new gas-chromatographic method for effective determination of pesticide residues
- Interspecies variability between man, rabbit and rat in function and structure of major xenobiotic transport proteins in the placenta
- Investigation of biomarkers of water pipe smoke
- Investigation of mixture effects of pesticides in vitro
- Investigation of the storage stability of pesticides
- Investigations on potential resident and bystander exposure from plant protection product uses in forest.
- Mechanism of toxicity of triazole fungicides
- Methodology to develop acute exposure threshold levels in case of accidental chemical release (ACUTEX)
- Nanoproducts for Plant Care and Protection
- On the evaluation of carcinogenic risks due to the exposure against dioxin-like and non-dioxin-like compounds
- Organotin compounds and aromatase activity: in vivo investigations during the pre-, peri- and postnatal development of rats
- Proteomanalyses of different liver tumors of mice with activating mutations in the oncogenes ß-Catenin, Ha-Ras and B-Raf
- Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances
- Proteomic analysis of benzo(a)pyrene responses in mouse tissues
- Scientific determination and assessment of consumer exposure to aniline derivative metabolites originating from plant protection products
- Spray-drift and volatilization related pesticide residues in untreated crops grown on adjacent areas
- Spray-drift and volatilization related pesticide residues in untreated crops grown on adjacent areas
- The effect of different sea water parameters on the formation of disinfection by-products anddisinfection efficiency
- Validation Study Human Exposure of Non-Professionals to Wood Preservatives
- Variability of cytochrom P450 enzymes in human lung tissue
Involved in research projects
Contact
BfR - Department 6: Chemicals Safety
(BfR - SiP)
Max-Dohrn-Str. 8-10
10589 Berlin
Berlin
Germany
Phone: +49-(0)30-18412-3337
Fax: +49-(0)30-18412-3008
Email: 6(@)bfr.bund.de