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BfR - Division 7: Chemicals and Product Safety (BfR - CPS)
Institution
Section overview
Description
The Chemicals and Product Safety Department assesses chemical substances that fall under the European chemical law (REACH Regulation (EC) 1907/2006). The objective is to ensure toxicological assessment, health risk assessment for consumers and the identification and initiation of necessary risk mitigation measures in accordance with the REACH Regulation. Assessments are also carried out with the aim of classifying and labelling of substances in accordance with the CLP Regulation (EC) 1272/2008.
In addition, the department is involved in the assessment of health risks that might be associated to cosmetic products, tobacco products, commodities (food contact materials, toys, baby bottles, teats, cleaning agents, garments, etc) as well as other consumer products (furniture, mattresses, carpets, DIY products, etc). It takes in account not only the existing knowledge gaps of science-based risk assessment but also the concerns of the general public in this field. Experimental projects on migration and exposure as well as the toxicity of chemicals present in these articles of daily use are an integral part of these assessment activities.
The remit of the department also includes the coordination and overall evaluation of risk assessments, the identification of data gaps and research needs for risk assessment and the initiation and supervision of internal and external research projects to support risk assessments.
Activities
- Research
Parent institution
Coordinated projects
- 2009: Development of a method suited to identify epigenetic effects in cells in culture upon exposure to low doses of model compounds, 2010: Investigation of epigenetic effects of consumer product-related model compounds in vitro
- 2009: Skin Penetration of Substances from Consumer Products 2010: Combined Migration and Skin Permeation of Phthalates from Consumer Products
- A mouse model for scrutinizing immuno-modulating effects of Xenobiotika and Pharmaka on the immune response of infections
- A pan-European infrastructure for quality in nanomaterials safety testing
- Activation of azo dyes to genotoxic metabolites by skin bacteria and studies for skin penetration
- Additives that increase addicitivness and attractivness of tobacco products
- Advancement of toxicological study parameters in human cell cultures
- Allergies and foreign body reactions in tattoo inks: identification of substances and influencing parameters
- Analysis of human samples on the presence and distribution of tattoo inks: Focus on allergens
- Analysis of the migration from elastomers used for food contact materials
- Analysis of the migration of elastomers from food contact materials
- Analysis of the quantitative influence of wood combustion on fine dust concentration in Berlin and Brandenburg using the tracer levoglucosan
- Analytische und Charakterisierung Exzellenz in der Risikobewertung von Nanomaterialien: Ein mehrstufiger Ansatz
- Assessment of dermal absorption of pesticides (DA Assessment)
- Assessment of potential synergistic or antagonistic toxicity mechanisms during co-exposition of in vitro models towards cerium dioxide nanoparticles and environmental chemicals/pharmaceuticals (NANOHEPATOX)
- Availability of health and environmental data for high tonnage chemicals under REACH - Phase II: More intensive REACH compliance check
- Availability of health and environmental data for high tonnage chemicals under REACH – Finalisation of Phase II and Phase III processing: substances with a registration of 100-1,000 t/a - REACH Compliance III
- Biochemical-bioinformatic analysis of reactive hepatotoxic substances in a hepatic co-culture system
- Cell cycle effects on the endocrine system and phase I metabolism
- Characterization of cellular effects of contact sensitizers in vitro: Analysis of phosphotyrosine signaling pathways by far western blotting and establishment of a screening method
- Characterization of contact allergen-specific responses in cocultures of human antigen presenting cells and T cells
- Characterization of metabolizing enzymes and biotransformation of selected test substances in human in-vitro skin models to identify an optimal test system for dermato-toxicological and exposure-related studies
- Chemical Imaging of Human Cells after Exposure to Metal Oxide Nanoparticles in vitro
- Classification of nanomaterials according to oxidative stress potential at the level of oxidative protein modifications
- Comparative study of the surface of kitchen utensil by means of a 3D scanner
- Control of cellular adhesion and uptake of synthetic polymer nanoparticles by specific functionalization with biological target molecules - NanoScale
- Cumulative Effects of Active Ingredients and Co-formulants in Plant Protection Products
- DENNA - Design criteria for sustainable nanomaterials
- Determination of chlorinated paraffins in food contact materials based on PCV and others
- Determination of chlorinated paraffins in nut nougat- or chocolate cream based on palm oil
- Determination of di-iso-butylphthalate (DiBP) and di-n-butylphthalate (DnBP) in paper and board packagings for infant formulae and in the packaged food
- Determination of perfluorinated compounds in simulants for contact with fatty food (simulant D)
- Developing analytical, imaging method for the identification of nanoparticles in cell lines (THP1 cells) as well as the elucidation of the effects obtained
- Developing analytical, imaging method for the identification of nanoparticles in cell lines (THP1 cells) as well as the elucidation of the effects obtained.
- Development and application of methods for the analysis of mineral oil components in body care products and cosmetics
- Development and evaluation of a method for the detection and quantification of volatile organic compounds (VOC) in consumer products
- Development and validation of a simple analytical method for quantification of mineral oil components MOSH and MOAH in foods based on conventional liquid chromatography and GC-FID
- Development of a 'Contact Allergen Activated T-Cell (CAATC)-Assay' using dendritic cells from skin: characterization of the sensitizing potency of chemicals via dendritic cell-induced expression of lineage specific T cell transcription factors
- Development of a contact allergen-induced T-cell assay using Langerhans cells: 2009: Expression of lineage specific T-cell transcription factors as biological endpoint suitable to indicate chemical induction of sensitization 2010: Measurement and quantification of transcription factors via qRT-PCR and FACS
- Development of an analytical, imaging method for the determination and localisation of nanoparticles in a cell line (THP-1 cells)
- Development of an LC-MS/MS method for the determination of perfluorinated compounds (PFCs) like fluortelomer alcohols, perfluorinated carboxylates (e.g. PFOA) and sulfonates (e.g. PFOS)
- Development of analytical multicomponent methods for the determination of dermal, oral and inhalative exposure towards plastic additives (e.g. phthalates) and NIAS in commodity goods.2015:Development of a multi-analyte method for the determination of phthalates in commodity goods. Inclusion of further additives such as stabilisers, catalysers, initiators and polymerisation aids.
- Development of methods for cleavage of azo dyes by human skin bacteria in vitro
- Development of screening assays for the assessment of the toxicity of migrants from commodities in keratinocytes
- Dynamics and reaction of the microbial skin flora after exposure to different carbon sources on artificial skin models
- Dynamics and reaction of the microbial skin flora after exposure to different carbon sources on artificial skin models
- Endocrine and DNA-damaging effects of complex mixtures relevant for consumer exposure
- Establishment and development of gentoxicity testing methods - Setup of the COMET assay for ingedients of product
- Establishment of an in vitro test platform for nanoparticle toxicity testing under physiologically relevant exposure conditions
- Establishment of diverse cell lines for the detection of epigenetic changes in single cell resolution
- Establishment of test systems for the identification of consumer-related substances with epigenetic activity
- Evaluation of data availability from the REACH registrations
- Examination and drafting of Summary Datasheets on toxicity data related to the evaluation by the CEF Panel of substances to be used in food contact materials
- Examinations of poly- or perfluorinated compounds in food contact materials
- Expert toxicological assessment of smoke constituents (ETASC)
- Expression analysis of drug-metabolizing enzymes in human keratinocytes after treatment with selected xenobiotics
- Expression of xenobiotic metabolizing cytochrome P450 (CYP)-dependent monooxygenases in human keratinocytes and permanent skin cell cultures
- Extent of metal release from food contact materials
- Genotoxicity testing in 3D model ? Establishment and adaptation of the COMET assay using a model for bronchial epithelia exposed to ingredients of consumer products
- Grouping, Read-Across, CharacterIsation and classificatiOn framework and strategies for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products
- Identification of novel molecular biomarkers enabling reliable assessment of endocrine distruptor activity in-vitro
- In vitro assay for the detection of epigenetic effects during the differentiation
- Influence of migrating substances on hepatic signalling
- Influence of temperature and residues of toxic industrial chemicals to the off-gassing behaviour of fumigated consumer products
- Inhibition of the transcription factor Nrf2 as a putative mechanism of toxicity exerted by compounds from dyes, glues and vulcanization accelerators in human keratinocytes (HaCaT)
- Integrated 'omics' approach for the identification of biomarkers for toxicological risk assessment of chemicals, nanomaterials and their mixtures including their potential to affect toxicologically relevant signaling pathways
- Investigation of cytotoxicity and genotoxicity of water pipe smoke
- Investigation of metabolites of the tobacco specific nitrosamine NNK, acrylamide and acrolein in urine of smokers of waterpipes
- Investigation of mutagenicity in the smoke of waterpipes and cigarettes
- Investigation on migration of substances and substance mixtures from colored textiles
- Investigation on the skin penetration and skin toxicity of polycyclic aromatic hydrocarbons
- Investigations on metabolism of the skin with in vitro models
- Investigations on the genotoxicity of formaldehyde in human cells in culture: Repair of DNA-protein crosslinks and identification of a 'threshold' dose for carcinogenic activity
- Investigations on the skin toxicity of polycyclic aromatic hydrocarbons
- Mechanical analysis of liver-toxic substances in a hepatic co-culture model
- Metabolism of polyaromatic hydrocarbons by the microbiome of the skin
- Method development for the characterisation and quantification of toxic volatile impurities from consumer goods, transported in fumigated shipping containers
- Method development for the characterisation and quantification of toxic volatile impurities from consumer goods, transported in fumigated shipping containers
- Method development for the identification of biomarkers for risk assessment of endocrine disruptors and phthalates
- Migration studies of nanotone-doped plastics for food contact
- Mixtures of PAHs in consumer products – Toxicity in human keratinocytes
- Modelling of dermal exposure and absorption based on experimental data from Franz cell ex-periments on the migration of substances from plastics and elastomers with uptake into the skin
- Molecular characterisation of the mechanism underlying teratogenic activity
- Mutagenicity and toxicity of water pipe smoke
- Nano-imaging methods for visualization of nanoparticles in vitro and in vivo: Analysis of uptake, distribution and quantitative assessment
- NanoGEM: Nanostructured Materials - Health, Exposition and Material Properties
- Nrf2-deficient human cell lines as a biological tool to screen for compounds of toxicological concern in consumer products.
- PERFOOD - Perfluorinated Compounds in our diet
- Perfuoroalkyl and polyfluoroalkyl substances in breast milk: Contents, time trends, relevance of influencing factors including individual consumption patterns and assessment for the breast fed infant
- Plasticizing substances from food packaged in glass containers with metal lids - analytics and exposition
- Production of textiles with defined composition and investigation of migrates
- Proof of sensitization in human dendritic cells of the skin in a migration assay and induction of T cell response in in-vitro models without animal experiments
- Proteomic analysis of cellular changes after treatment with contact allergens in human monocytic cell lines and in primary dendritic cells. 2017: Transcriptomic and proteomic Analysis of T cells and monocyte-derived dendritic cells
- Proteomic analysis of oxidative stress after nanoparticle treatment in cell culture to study cytotoxicity mechanisms
- Public Information Tobacco Control (PITOC)
- Qualitative and quantitative analysis of toxicological relevant matters in the mainstream smoke of the waterpipe
- Quantification of the migration of polycyclic aromatic hydrocarbons (PAHs) from various consumer products at regular handling conditions
- Scented toys: Exposure of infants against allergenic scents - Research on the analysis and biological effects of allergens in toys
- Science-based grouping of nanomaterials for industrial application of safe-by-design
- Screening assays for toxic and sensitizing substances in mixtures of azo dyes and its metabolites using human keratinocytes
- Skin penetration in vitro
- Skin toxicity of commensal metabolites of polycyclic aromatic hydrocarbons
- Species selectivity of exogenous and endogenous aryl hydrocarbon receptor ligands
- Studies on skin penetration of ingredients of cosmetics and commodities using in-vitro methods
- Studies on the allergenic potential ingredients of commedities and cosmetics using the local lymph node assay
- Studies on toxicity and genotoxicity of substances from commodities, e.g. azo dyes and vulcanisation aids
- Tattoo inks: chemical characterization and distribution in the human skin
- Test procedure and sample for instrument performance control in 3D depth profiling for organic materials by ToF SIMS
- The inflammatory milieu in human skin affected by chemical contact allergens
- The inflammatory milieu in human skin affected by chemical contact allergens
Involved in research projects
Contact
BfR - Division 7: Chemicals and Product Safety
(BfR - CPS)
Max-Dohrn-Str. 8-10
10589 Berlin
Berlin
Germany
Phone: +49-(0)30-18412-4538
Fax: +49-(0)30-18412-4928
Email: 7(@)bfr.bund.de
