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Imprint
Biokinetic of the rare sugar D-Allulose in human blood and urine
Project
Project code: MRI-PBE-08-2020-39-Allulose
Contract period: 01.05.2021
- 31.05.2023
Purpose of research: Experimental development
High consumption of drinks sweetened with sugar (glucose, fructose, sucrose) is associated with overweight and obesity. Low calorie alternatives for these caloric sugars, that equal their sweetness and functionality. One possible alternative is the rare sugar allulose (also psicose) that matches traditional dietary sugars in taste and physical-chemical characteristics in food production. After consumption most of the allulose is excreted via urine and only a small amount is metabolized resulting in a caloric value 5-10% of traditional dietary sugars. Allulose is used in food production in some countries and several proposals to use allulose as a novel food are currently evaluated by the EFSA. Some studies assessing the effects of allulose in humans suggest that its consumption might positively affect bodyweight and carbohydrate and fat metabolism. However, data on the biokinetics of allulose, namely its concentrations in blood and excretion rate in urine, are currently unknown. These data are needed to study the effects of allulose on metabolism in humans in greater detail. The proposed study will close this gap in knowledge. In a crossover design healthy women and men will consume various doses of allulose. In the following 24h, all urine will be collected in fractions and blood samples will be taken at several timepoints. Allulose concentrations will be measured in all samples and lay the basis for the calculation of bioavailability, half-time, clearance and metabolism of allulose. Relevant metabolites will be measured to assess possible effects on carbohydrate and fat metabolism.
Section overview
Subjects
- Food Chemistry
Framework programme
Funding programme
Excutive institution
MRI - Department of Physiology and Biochemistry of Nutrition (MRI-PBE)
