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Imprint
Investigations on the virulence potential of influenza viruses
Project
Project code: 2813101006
Contract period: 01.01.2007
- 31.01.2010
Budget: 491,929 Euro
Purpose of research: Experimental development
The virulence of influenza viruses is not determined by one viral protein or genome segment alone. In birds (mainly waterfowl), replication of influenza viruses of all subtypes (HA1-HA16) is observed. Most of these influenza viruses are low pathogenic (lpAIV) for chickens and only cause mild organ changes. Exclusively viruses of the subtypes H5 and H7 can generate highly pathogenic variants (HPAIV) which cause classical fowl plague with severe clinical symptoms. The study aims to clarify whether HA of other subtypes are also able to induce high pathogenicity. Therefore, the reverse genetic system for influenza viruses previously established will be used to generate recombinant influenza viruses (also with neuraminidases of influenza viruses of different virulence). Their virulence will be analysed in animal studies only.
Section overview
Subjects
- Animal health
Funding programme
Excutive institution
FLI - Institute of Molecular Virology and Cell Biology (FLI - IMVZ)
