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Collaborative project: Community project: Early diagnosis of infections with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle – Subproject 1
Project
Project code: 2813200606
Contract period: 01.04.2007
- 30.06.2010
Budget: 917,729 Euro
Purpose of research: Experimental development
Mycobacterium avium subspecies paratuberculosis (MAP) is causative agent of the Paratuberculosis, which is a world-wide disease in cattle. Economic losses as well as a possible association of this agent with Crohn’s disease of humans justify a consistent eradication of the disease. This fails so far because of insufficient diagnostic conditions. Cattle infect themselves mostly at the calf age. However, a reliable detection succeeds only after the 2nd year of life. One aim of this project is the development of innovative procedures which can be use as standard diagnostic tool for early detection of MAP-infections in calves: 1) Minimal invasive sampling of lymph node biopsy; 2) Detection of MAP DNA in biopsy by real time PCR assay; 3) Detection of MAP-specific anti-bodies and T-cell population in the peripheral blood by using flow cytometry. Among others this study includes a long-term investigation of experimentally infected calves as well as a horizontal cohort study in dairy cattle herds in order to develop and validate these procedures for the routine practice.
Section overview
Subjects
- Animal health
