We use cookies on our website. Some are necessary for the operation of the website. You can also allow cookies for statistical purposes. You can adjust the data protection settings or agree to all cookies directly.
Data Protection Declaration
Imprint
Collaborative project: Novel approach for the development of a heterosubtypic marker vaccine against avian influenza in poultry – Subproject 2
Project
Project code: 2813200706
Contract period: 01.03.2007
- 30.11.2010
Budget: 302,137 Euro
Purpose of research: Experimental development
The aim of the project was i) to identify a live Salmonella vaccine as carrier strain for antigens of the avian influenca (ai) virus, ii) to test an effective expression system for ai-antigens in chickens, iii) to establish an effective vaccination scheme, iv) to study the virulence and the ability of ai-vaccine strains to induce a humoral immune response, and v) to examine the protective effects of the oral immunisation of birds with live Salmonella-ai vaccine candidates against challenge using a highly pathogenic ai-virus of subtype H5. A live Salmonella vaccine strain could be identified as appropriated carrier strain for ai-antigens. This strain showed in comparison with 4 other vaccine strains a stronger ability to colonise the gut and to invade internal organs. Using this Salmonella carrier strain studies on establishing an effective vaccination scheme were carried out. To induce highly protective effects, there is a strong need to start immunisation of chickens on day 1 of life. Different Salmonella-ai-vaccine candidates were tested for both their colonisation and invasion capability and their ability to induce protective effects against ai-challenge in chickens. Significant differences between vaccinated and non-vaccinated birds against infection with a highly pathogenic ai-virus of subtype H5 were not observed. However, important information to modify both the Salmonella-ai-vaccine candidates and the vaccination scheme were gained.
Section overview
Subjects
- Animal health
Funding programme
Excutive institution
FLI - Institute for Bacterial Infections and Zoonoses (FLI-IBIZ)
Funding institution
Project management agencies
Associated projects: Collaborative project: Novel approach for the development of a heterosubtypic marker vaccine against avian influenza in poultry
- Collaborative project: Novel approach for the development of a heterosubtypic marker vaccine against avian influenza in poultry – Subproject 1
- Collaborative project: Novel approach for the development of a heterosubtypic marker vaccine against avian influenza in poultry – Subproject 1 (following project)
