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Collaborative project: Chicken Synthetic Microbiota – Development of a microbial consortium for the early colonization of the chicken intestine in broiler production - subproject B (ChiSYN)
Project
Project code: 281C402B21
Contract period: 01.03.2023
- 30.04.2026
Budget: 821,120 Euro
Purpose of research: Applied research
Keywords: animal feed, antibiotics, animal health, bacteriology, poultry, animal welfare, prevention
ChiSYN will develop a bacterial consortium for oral application to increase the resilience of chicken against bacterial infections which in turn will contribute to the reduction of antibiotic use in broiler production. Using bioinformatic tools, bacterial isolates from the chicken intestine with important metabolic functions and the genetic potential to exert beneficial effects on the immune system and to increase the colonization resistance against intestinal pathogens. Selection criteria also include the absence of genetic traits with relevance for human, animal or environmental safety and registration as a feed additive. In addition, proprietary bioinformatic tools will be applied to select those bacteria that can be produced at economic reasonable conditions. Effects of selected organisms on host immune functions and inhibition of pathogens will be tested in cell culture assays, in enteroids and with microbiological methods, respectively. Using a unique model of the chicken intestine, colonization behavior and responses of gut microbiota to the consortium will be evaluated. Broiler trails under experimental and under commercial conditions will be conducted to confirm the relevance of observed effects for the animal. Production processes will be developed for consortia with proven efficacy with a strong focus on economic feasibility, formulation, and application at customer sites. The final prototype will be further developed by the industry partner taking advantage of vast experience in and well-established processes for feed additive development, product launch and marked development including safety assessment, product registration and industrialization of production processes. This highly integrated approach will facilitate the fast translation of scientific excellence into a feed additive to reduce antibiotic use in broiler production.
Section overview
Subjects
- Animal health
- Animal nutrition
Framework programme
Funding programme
Excutive institution
Funding institution
Project management agencies
Associated projects: ChiSYN
- Collaborative project: Chicken Synthetic Microbiota – Development of a microbial consortium for the early colonization of the chicken intestine in broiler production - subproject A
- Collaborative project: Chicken Synthetic Microbiota – Development of a microbial consortium for the early colonization of the chicken intestine in broiler production - subproject C
