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Imprint
Computerised risk assessment of dermal absorption of active agents
Project
Project code: BfR-ZEBET-08-1328-177
Contract period: 01.11.2004
- 31.10.2008
Purpose of research: Applied research
To predict the absorption or distribution of active agents in the skin only very simplified computerised models are available up to now. Thus, the predictability of dermal risk assessment is vey limited. Particularly, the influence of the vehicle or preparation is not included in these models, and therefore, the absorption of new pharmaceuticals and cosmetics but also new chemicals have to be tested on real subjects, i.e. mainly on living animals. The aim of this project is to realize a computerised predictability of the skin absorption of various chemical agents including their physical-chemical properties and the interaction of the formulation used. In contrast to the currently used computerised models the new model is based on the mathematical description of the diffusion process in the skin. Since appropriate data is rarely available in the literature, experiments on human skin with substances, covering the hydrophilic and lipohilic range, in various formulations, e.g. hydrophilic
Section overview
Subjects
- Food Chemistry
Framework programme
Funding programme
Excutive institution
BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET)
