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GRK 1029 P1A: Role of the vitamin D hormone system for insulin secretion in swine
Project
Project code: DFG GRK 1029
Contract period: 01.01.2005
- 31.12.2010
Purpose of research: Basic research
It is the aim of this dissertation project to characterize the alterations in insulin synthesis and secretion in PVDRI pigs by in vivo and ex vivo experiments. Because hypocalcemia is a strong factor influencing insulin secretion, it is a prerequisite for this subproject to establish the methods necessary to normalize calcium and phosphorus blood levels in PVDRI pigs. In vivo insulin secretory capacity in normo- and hypocalcemic PVDRI pigs will be determined by oral and parenteral glucose tolerance tests. Using a number of different stimuli, insulin secretion in isolated islets from wild-type and PVDRI pigs will be measured in ex vivo experiments.
Section overview
Subjects
- Animal health
