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Investigations on the pathogenesis of the haemorrhagic syndrome and on the organ tropism of highly virulent H5N1 isolates in different species
Project
Project code: 2813101206
Contract period: 01.01.2007
- 31.12.2009
Budget: 557,011 Euro
Purpose of research: Experimental development
The clinical course of avian influenza virus infections in domestic poultry varies between asymptomatic infection, mild respiratory symptoms and severe systemic disease with 100% mortality, which manifests as haemorrhagic diathesis with shock. An important factor seems to be the extreme virulence range of influenza viruses. Interestingly, HPAIV has a distinct endotheliotropism. Another pathogenetic factor is the affected animal species. In swans the fulminant course of disease can be explained by both, neuro- and endotheliotropism, while in infected mammals (cats) pneumotropism evidently plays the major role. Prior to generalisation, these individual findings must be verified in extensive pathogenetic studies in different bird species (chicken, duck, goose, swan) and mammalian species (domestic pig, wild boar, fox, rat, mouse, ferret). Non-vertebrates, such as annelids or arthropods should also be taken into account as vectors.
Section overview
Subjects
- Animal health
- Special animal species
- Wildlife Biology
- Biotechnology
