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Investigations on the induction of the unspecific and specific immune response after H5N1 influenza virus infection
Project
Project code: 2813101106
Contract period: 01.01.2007
- 31.12.2009
Budget: 653,007 Euro
Purpose of research: Experimental development
Virus infections lead to the induction of an early unspecific cellular immune reaction of NK cells and a subsequent specific immune response by T cells. The aim of this project is the characterisation of the immune response after infection with H5N1 influenza viruses to achieve an acceleration of the antiviral immune response and thus a reduction of the virus titre in the lung or even an elimination of the virus by specific stimulation of the immune system. For this purpose, the kinetics and specificity of the antiviral cellular immune reaction after isolation of the corresponding effector cells from the lung or from the blood will be investigated in selected animal models. We will identify viral peptides, against which such an immune reaction is induced, and analyse the spectrum of the locally synthesised cytokines and antibodies. Using different stimulants of the immune system, such as interferon, we will investigate whether after infection with H5N1 the infection can be influenced by an early induction of the immune response.
Section overview
Subjects
- Animal health
- Biotechnology
