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Imprint
Characteristics of the local distribution of the Y139C resistance gene in Norway rats (Rattus norvegicus) in a focus of resistance in Westphalia, Germany
Project
Project code: JKI-GF-08-1167
Contract period: 01.12.2010
- 31.12.2013
Purpose of research: Applied research
Description of the first project part:
The Westphalia resistant rat strain is marked by the Y139C polymorphism of the vkorc1 gene, which leads to practical resistance against anticoagulants warfarin, coumatetralyl, bromadiolone and difenacoum. All former field investigations were performed on farms, which were peculiar for their rat control problems, assumed to be hot spots of resistance. Almost nothing is known about the distribution of resistant rats on estates, which became not obvious for resistance due to control problems in the resistance area. The incidence of resistance around hot spots in the resistance area were not analyzed.
For the project rats were trapped at a single infested site in each of 12 squares (1km x 1km) in a line including a resistance hot spot. Tissue samples were taken from all trapped rats and genotyped for the Y139C variant of the vkorc1 gene.
Description of the second project part:
Beside management deficits intensive exchange between the populations by dispersal processes could be the reason for the wide distributions of Y139C rats. However dispersal processes and resulting genetic distances between the natural populations in the cultural prone area of Westphalia is completely unknown. Therefore we investigate furthermore genetic distance between the individuals of the sampled populations. This part of the study is still ongoing.
Section overview
Subjects
- Animal health
- Special animal species
Framework programme
Funding programme
Excutive institution
Institute for Plant Protection in Horticulture and Forests (JKI-GF)
