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Transferable antimicrobial resistance among MRSA and MSSA from humans and animals
Project
Project code: keine Angabe
Contract period: 01.11.2010
- 31.10.2013
Purpose of research: Basic research
Antimicrobial resistance genes in Staphylococcus aureus are often located on mobile genetic elements which can undergo integration and recombination events, resulting in strains with novel types of resistance plasmids or combinations of plasmids conferring resistance and virulence. Moreover, an integration of plasmids and transposons into the chromosomal DNA has also been observed in Staphylococcus aureus strains. So far, only a limited number of Staphylococcus aureus plasmids of >20 kb has been sequenced completely. In this project, we will conduct detailed analysis of (a) large resistance plasmids of Staphylococcus aureus strains (MRSA and MSSA) from humans and animals and (b) the SCCmec cassettes of MRSA strains. Based on the strain characteristics provided by other groups of the network, Staphylococcus aureus strains which differ (a) in their virulence and (b) in their host spectrum (extended-spectrum, i.e. zoonotic genotypes vs. restricted-spectrum genotypes) will be included. Resistance plasmids and SCCmec cassettes of these strains will be investigated not only for the co-localization of different resistance genes, but also for the co-localization of virulence/colonization genes to better understand the dissemination and persistence of resistance as well as the simultaneous acquisition of novel virulence properties and host colonization factors in Staphylococcus aureus.
Section overview
Subjects
- Animal health
