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Collaborative project: Development of a highly effective and biologically safe phage technology for pathogen control in poulty farming (SafePhage) – Subproject 2
Project
Project code: 2817601212
Contract period: 01.10.2014
- 30.09.2017
Budget: 138,161 Euro
Purpose of research: Experimental development
The SafePhage project is aimed at the development of a novel, phage-based technology for pathogen control in poultry farming. Our approach is based on the application of cocktails of modified (non-reproductive) lytic phages. We have chosen Salmonella and Clostridium perfringens as model pathogens. Both species have an outstanding impact on poultry farming. Furthermore, they are among the most important causes of foodborne infections and poisoning in humans. The high degree of diversity within both microorganisms will facilitate transfer of the novel phage technology to a wide range of other bacterial pathogens in livestock farming. Following the initial target host range definition, we plan to isolate strictly lytic phages and determine their host range and stability. Selected individual phages will be produced at a small scale und fully characterized. During the next phase of the project, we will generate non-reproductive variants. These phage mutants will be formulated and their efficacy will be determined. Following that, we will develop a scalable production process for the non-reproductive phages. We then plan to formulate the phage cocktails and determine their properties in the lab. Finally, we will perform application studies on poultry to investigate efficacy and safety and to validate the novel phage technology.
Section overview
Subjects
- Animal breeding
- Animal health
