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Imprint
Immunomodulatory effects of food ingredients
Project
Project code: MRI-PBE-08-04
Contract period: 01.01.2001
- 31.12.2016
Purpose of research: Basic research
Sustained imbalances of the immune activation can significantly increase the risk to develop chronic diseases. Physiological conditions are characterized by well-balanced activating and inhibiting immune reactions whereas prolonged overactivation of the immune system can lead to pathological inflammatory reactions with the potential to initiate and maintain autoimmune processes. A continuing diminished immunoreactivity on the other hand favors prolonged or repeated infections or even the infection with opportunistic pathogens. A variety of factors can control the activation, inhibition and homeostasis of the immune system with consequences for the permanent course of the basic cellular and humoral immune responses. Especially foods and their ingredients show potential to shift the homeostasis of the particular immune components and thus modulate immune reactions in a natural way. In the light of the above, research of the immune regulatory potential of food ingredients during physiological conditions is of particular relevance as it helps to understand how our diet might act on basic immunological processes. The aim is to characterize the potential of food ingredients to influence the development, maintenance and expression of cellular and humoral immune responses that go beyond the studies of the gut-associated immune system. The idea is to investigate how far-reaching foods might affect the immunological network.
Jaudszus A, Mainz JG, Pittag S, Dornaus S, Dopfer C, Roth A, Jahreis G.: Effects of a dietary intervention with conjugated linoleic acid on immunological and metabolic parameters in children and adolescents with allergic asthma – a placebo-controlled pilot trial. Lipids in health and disease. 2016 Feb;15(21):1-12.
Jaudszus A, Lorkowski S, Gruen M, Roth A, Jahreis G.: Limited Applicability of GW9662 to Elucidate PPARγ-Mediated Fatty Acid Effects in Primary Human T-Helper Cells. International journal of inflammation. 2014 Jun; 149628:1-6.
Jaudszus A, Gruen M, Watzl B, Ness C, Roth A, Lochner A, Barz D, Gabriel H, Rothe M, Jahreis G.: Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. Journal of lipid research. 2013 Jan;54(4):923-35.
Graf D, Seifert S, Jaudszus A, Bub A, Watzl B.: Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats. PlosOne. 2013 Jun; 8(6):1-5-e66690.
Section overview
Subjects
- Physiology of Nutrition
Framework programme
Funding programme
Excutive institution
MRI - Department of Physiology and Biochemistry of Nutrition (MRI-PBE)
