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Data Protection Declaration
Imprint
Transfer of the LivSys in vitro system for hepatotoxicity into application (LivSys-Transfer)
Project
Project code: BfR-LMS-08-1334-228
Contract period: 01.01.2017
- 31.12.2019
Budget: 170,178 Euro
Purpose of research: Applied research
Risk Assessment of toxic properties of chemicals and subsequent regulation by law is preliminary based on data obtained from animal experiments. Due to ethical reasons alternative methods shall be developed in order to reduce the number of animal experiments in the long term. In the e:ToP pilot phase a set of seven genes with altered gene expression in the presence of hepatotoxic substances was identified by using human liver cells. Aim of the project is to demonstrate the applicability of the 7-gene signature for the prediction of hepatotoxic effects of test substances by using cell culture models (“proof of principle”). A broad set of known hepatotoxic and non-hepatotoxic substances will be used to examine whether the prediction based on the 7-gene signature leads to correct positive and negative results, respectively. Moreover, the data obtained from cell culture experiments will be correlated with known blood serum levels of the substances in order to employ computer models for the deviation of human-relevant hepatotoxic concentrations.
Section overview
Subjects
- Toxicology
