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Development of an analytical, imaging method for the determination and localisation of nanoparticles in a cell line (THP-1 cells)
Project
Project code: BfR-PRS-08-1329-417
Contract period: 01.09.2009
- 31.12.2012
Purpose of research: Applied research
According to the investigations of the Woodrow Wilson institute the number of nano-enabled consumer products increased nearly fivefold from 2006 to 2009. A similar trend was ob-served for food contact materials. It is anticipated that this general tendency is continued.In accordance with the report of the Woodrow Wilson institute from August 2009 especially silver nanoparticles are the most commonly used nanoparticles in consumer products.The antimicrobial effect of silver is the primary function of these nanoparticles.On the one hand at an increasing degree it is possible for the consumer to encounter vari-ous products (refrigerators, food storage containers, textiles) modified with nanoparticles, on the other hand there are considerable gaps in the understanding of the health risks arising from nanoparticles.In general we are at the beginning to comprehend the conceivable, specific toxic properties of nanoparticles caused by their scale.In order to evaluate the toxicological risk of nanoparticles, it is necessary to develop meth-ods for the identification and characterization of nanoparticles at a cellular level.It is the aim of this project to develop an analytical imaging procedure for the identification and localisation of silver-nanoparticles in individual cells.A robust procedure should give us a better understanding of the mode of action as to indi-vidual cells to attain a better risk assessment.
Section overview
Subjects
- Biotechnology
