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Assessment of dermal absorption of pesticides (DA Assessment)
Project
Project code: BfR-SiP-08-1322-606
Contract period: 01.01.2014
- 31.12.2016
Purpose of research: Basic research
The extent of absorption of an active substance across the skin represents one of the major factors for the outcome of risk assessments for pesticides and biocides. Therefore, the dermal absorption is frequently influencing the decision about product approval and/or the choice of risk mitigation measures. At the same time, there are differences in the way the information on dermal absorption is interpreted by the competent authorities, causing deviating assessments. Although some guidance documents and guidelines are available on the issue, these leave room for interpretation, are conflicting in some cases and are not fully accepted by all. This project aims to improve the situation by addressing several of these open questions that have been collected from our risk assessment practice using a unique BfR Database. This database has been created 2010-2012 based on studies submitted for pesticide assessment until January 2011. The database will be updated with information from studies submitted of 2011-2015 and extended by further parameters, namely physico-chemical parameters like solubility and formulation descriptors. Results of the projects are provided to the EFSA Working Group on Dermal Absorption for ongoing revision of the Guidance document.
The BfR database Dermal Absorption was updated and extensions for formulation data were successfully tested. The information from the database was evaluated and served to revice recommendations of the EFSA Guidance on Dermal Absorption on study conduct and evaluation. Finally, the in silico – in vitro relationship was poor for all QSARs examined. Improvements may be made by taking into account formulation properties. The most reliable model for predicting DA of pesticides was IH Skin Perm with 38% of the cases being predicted within one order of magnitude and the lowest percentages of underpredicted (2%) as well as highly overpredicted cases (15%).
Section overview
Subjects
- Toxicology
