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SFB 670 TP1: The professional phagocyte Dictyostelium as a host model for pathogens
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
To be able to cope with potential pathogens most organisms have developed elaborate defense mechanisms. They often harbor specialized cells that have the ability to rapidly and efficiently internalize a variety of organisms and particles and degrade them. Macrophages, myeloid dendritic cells, neutrophils represent professional phagocytes that are important for innate and adaptive im-munity. We use Dictyostelium discoideum, a professional phagocyte, to analyse the process of phagocytosis at the molecular level. The studies involve mutant analysis, live cell imaging as well as biochemical experiments.
Section overview
Subjects
- Animal health
