We use cookies on our website. Some are necessary for the operation of the website. You can also allow cookies for statistical purposes. You can adjust the data protection settings or agree to all cookies directly.
Data Protection Declaration
Imprint
SFB 670 TP4: Role of sphingomyelinase for the membrane-bound antibacterial effector mechanisms
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
Recruitment of antimicrobial enzymes to the phagosome via vesicular transport processes essentially contributes to the regulation of oxidative and non-oxidative antibacterial mechanisms. We have previously shown the importance of acid Sphingomyelinase (ASMase) for the control of intra-cellular bacteria. In this project we aim at characterizing the molecular mechanisms by which the lipid-modifying activity of ASMase regulates vesicular processes, e.g. maturation of phagosomes, phago-lysosomal fusion, translocation of the NADPH oxidase complex, and autophagy.
Section overview
Subjects
- Animal health
- Biotechnology
