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SFB 670 TP6: Role of p47 (IRG) GTPases in cell-autonomous resistance to protozoal pathogens
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
The interferon-inducible p47 (IRG) GTPases are major effectors of cell-autonomous immunity in mice against vacuolar pathogens. Little is known about their mechanism of action. We have proposed that the action of the p47 GTPases in Toxoplasma immunity is mediated through the vesiculation and ultimately the destruction of the parasitophorous vacuole membrane. Our work is designed to examine this hypothesis experimentally, and to see whether it can be extended to account for our unpublished finding that loss of one p47 GTPase, IIGP1 Irga6, results in heightened susceptibility in mice to the malarial pathogen, Plasmodium berghei.
Section overview
Subjects
- Animal health
