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Imprint
SFB 670 TP8: Inhibition of AAV infection by intracellular defence mechanisms
Project
Project code: DFG SFB 670
Contract period: 01.01.2006
- 31.12.2010
Purpose of research: Basic research
Until recently 11 different AAV serotypes have been described, which differ in their tropism due to the use of different cellular receptors and to differences in the cellular reaction towards the infection. Hepatocytes provide a strong example. Less than 10% of hepatocytes in mouse livers are stably transduced with AAV2, although nearly all hepatocytes contain vector genomes 1 day after injection. The use of other serotypes, which contain the same genome, results in a remarkably higher transduction efficiency (e.g. up to 97.4% with AAV8), which suggests a cellular defence mechanism against AAV2 capsids. In this study, we aim to analyse these mechanisms in detail.
Section overview
Subjects
- Animal health
