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Gastrointestinal exposure to nanoscale iron compounds in foods: absorptive pathways and potential toxicity
Project
Project code: NFP64-3-2
Contract period: 01.12.2010
- 30.11.2013
Budget: 452,064 Euro
Purpose of research: Applied research
The human body is well able to absorb and utilise nanostructured iron compounds. Such compounds are therefore of interest for the iron fortification of foods. In this project, we aim to study the absorption mechanisms and the potential toxicity of such compounds.
Background
In earlier studies we were able to show that nanostructured iron compounds are readily bioavailable and often have reduced reactivity in foods that otherwise react very strongly with readily available iron compounds. Therefore these nanostructured compounds may be suitable for nutritional applications such as iron fortification or supplementation of foods.
Aim
The aim of this project is to investigate the absorption mechanisms of nanostructured iron compounds in the gastrointestinal tract. Normally iron is dissolved in the stomach and absorbed in the intestine by a specific transporter. This way of absorption is most likely also involved in the absorption of iron from nanostructured compounds. However, it is also possible that alternative absorption pathways, e.g. endocytosis, are of importance in the uptake of these compounds. Thus the absorption will be investigated in in vitro and in vivo models. In addition, we will investigate the toxicity of the compounds in in vitro and in vivo models as well.
Significance
Many studies have examined the absorption and toxicity of nanoparticles in the lung. Yet little is known about the absorption of nanoparticles in the gastrointestinal tract. With our experiments we hope to close this gap. We will clarify whether the use of nanostructured compounds is feasible in foods and whether there are any health risks associated with it. Combining mechanistic and toxicity studies with the extensive analysis of biomarkers in vitro and in vivo, we will prepare a set of tools for the investigation of other nanoparticles as well.
Section overview
Subjects
- Physiology of Nutrition
- Toxicology
